Words similar to obstacle

Example sentences for: obstacle

How can you use “obstacle” in a sentence? Here are some example sentences to help you improve your vocabulary:

The Thernstroms say they recognize that racial discrimination, though dramatically diminished, continues to pose an obstacle to African-Americans.
Today's installment in the series about women in the military that the WP started yesterday focuses on a little-noticed obstacle confronting women officers trying to rise to top command jobs: a key route for getting them is serving as an aide-de-camp to those in them now, and the top brass hardly ever pick women.
The biggest obstacle, says the Times , is Jesse Helms, whose main interest in the area of nuclear weaponry is not traditional arms control, but enhanced anti-missile defenses.
A highly ordered chromatin structure presents a physical obstacle for gene transcription; presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] . In concert with the observation that corepressors are associated with HDAC activities [ 84 85 ] , it appears that the transcriptional outcome of nuclear receptors is determined by the balance of histone acetylation and deacetylation activities, and that ligands serve as a switch to recruit HATs with the concomitant dismissal of HDACs.
(But the LAT notes a possible obstacle: the House managers are continuing to press for live testimony.)