Words similar to obstacle

Example sentences for: obstacle

How can you use “obstacle” in a sentence? Here are some example sentences to help you improve your vocabulary:

A highly ordered chromatin structure presents a physical obstacle for gene transcription; presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] . In concert with the observation that corepressors are associated with HDAC activities [ 84 85 ] , it appears that the transcriptional outcome of nuclear receptors is determined by the balance of histone acetylation and deacetylation activities, and that ligands serve as a switch to recruit HATs with the concomitant dismissal of HDACs.
The LAT lead about Clinton's U.N. appearance covers the same basic material, but also has some good background on the test-ban treaty, stating that the chief domestic-policy obstacle to a ban since Eisenhower first sought one is the fear that the United States cannot maintain its nuclear deterrent without testing.
It is possible that disrupting the geometry of these inhibitors creates an obstacle to growing neurites.
The diminutive jockey drives on the handsome steed which has its two front legs raised into the air, as if about to leap over an invisible obstacle.
Today's installment in the series about women in the military that the WP started yesterday focuses on a little-noticed obstacle confronting women officers trying to rise to top command jobs: a key route for getting them is serving as an aide-de-camp to those in them now, and the top brass hardly ever pick women.