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Example sentences for: observations
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Taken together, these observations could explain the occurrence of CVID or IgGSD and hemochromatosis due to HFE C282Y homozygosity in some of the present index patients [ 26 ] and account for the occurrence of IgA deficiency and hemochromatosis in different members of the same family [ 27 ] .
A significantly increased absolute frequency of the haplotype A*03-B*35 has also been reported in hemochromatosis patients in Italy [ 29 ] . The present observations regarding this haplotype may be attributable to the large subgroup of persons of Italian and Sicilian descent in central Alabama [ 44 ] . A significantly increased frequency of the haplotype A*03-B*15 was observed in the present Alabama hemochromatosis probands, whereas a relative increase in this haplotype was detected in hemochromatosis cohorts in Brittany and Utah only after "correction" of the data for the preponderance of other haplotypes [ 2 20 ] . Similarly, a significantly increased frequency of the haplotype A*03-B*44 was observed in the present Alabama hemochromatosis probands, whereas a relative increase in this haplotype was detected in hemochromatosis cohorts in Sweden, Brittany, and Utah after "correction" of the data for the preponderance of other haplotypes [ 2 8 19 ] . The absolute frequency of the haplotype A*03-B*47 was increased in central Alabama hemochromatosis probands, whereas a "corrected" frequency of A*03-B*47 was increased in hemochromatosis patients from Denmark [ 8 ] . The other aforementioned haplotypes (except A*03-B*07 and A*03-B*14) have not been reported to occur with increased frequency in any hemochromatosis cohort from locations other than Alabama.
We wished to determine whether our observations of groups reflect this division, so we divided our dataset in two, creating one dataset of 'embryo' experiments and one of 'adult' experiments.
The idea of using PM-only information is based on the following observations: MAS4 essentially discards the one-one correspondence between a PM and its MM partner (for details, see materials and methods on MAS4 algorithm for absolute analysis) and still gives satisfactory interpretation, which suggests the contribution of MM probes might be approximated in a nonspecific manner overall.
Furthermore our observations suggest that in vivo, brain microglia as well as the mediators released by this cell type in brain tissue, would appear to play a limited role in the rapid and potent domoic acid neurotoxicity observed in neonatal rats after a short-term administration of domoic acid.
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