Words similar to obligatory
Example sentences for: obligatory
How can you use “obligatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
Injured adult DRG neurons do not die after axonal injury [ 15 ] as a result of the upregulation of cell survival factors such as the small heat shock protein HSP27 [ 16 ] . We now find several genes that could have a survival-promoting role, including the peripheral benzodiazepine receptor, whose agonists are potent antiapoptotic compounds [ 17 ] , GADD45A, which maintains genomic stability and appears to be anti-apoptotic in neurons after ischemic damage [ 18 ] , metallothionein 1L, which is a free radical scavenger [ 19 ] , GTP cyclohydrolase 1, which is obligatory for the actions of NGF on PC12 cells [ 20 ] , and IES-JE (MCP-1) which attracts macrophages, which in turn have been reported to have a role in neuronal survival [ 21 ] .
The execution is even more problematic: There is an abundance of bad acting, heavy-handed moralizing, obvious dialogue--and, of course, the obligatory elderly Indian skulking about to highlight the mysticism of the situation.
Post-transcriptional gene silencing using synthetic short interfering RNA (siRNA) molecules has been recently used to ablate specific mRNAs and thus, produce phenotypic mutations in specific genes [ 16 17 ] . We have adopted this technology to knockdown specific gene products in RNA viruses that are obligatory intracellular parasites [ 18 ] . In the present study, we have successfully used a similar strategy to generate phenotypic PP1-deficient P. falciparum parasites.
In particular, the apparently obligatory roles of E204 and E194 in fast H +release in bR are not matched in pR.
This study explores the effect of alteration of the GC environment during late gestation, with the expectation that suppression of GC effects will improve the LIFR null newborn phenotype and identify LIFR as an obligatory player in concert with the maternal GC surge during late gestation development.
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