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Example sentences for: ob

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Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.
6%, of patients with Obesity III had ADHD, that is, the OB+ADHD population was concentrated in the obesity class having the highest mortality and morbidity risks, and greatest need for effective treatment.
Moreover, no special measures were taken to reduce or account for such biases during the course of diagnosing patients in the present sample, rendering it quite difficult to estimate how much and what kind of effect biases have had on the above reported prevalences of OB+ADHD.
On the other hand, using the same adrenalectomy protocol that produced a similar reduction, but not elimination, of plasma corticosterone levels, we observed a remarkable reversal of obese phenotypes in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the reduction of corticosterone by adrenalectomy in the present study was sufficient to produce elevation of pituitary POMC mRNA (as well as hypothalamic POMC mRNA), demonstrating that the reduced levels were clearly producing physiological effects.
The prevalence of OB+ADHD in this report is plausibly within the range of these studies.