Words similar to ob
Example sentences for: ob
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Folds such as the SH3-like barrels, the PAS-like fold, the OB fold, the double-stranded β-helix, the β-propeller and rubredoxin-like zinc ribbons are predominantly non-catalytic domains that are widely represented in multiple functional contexts, with roles such as small-molecule binding, nucleic-acid binding and interaction with other proteins [ 3, 4, 5] (see also the SCOP [ 6] and CATH [ 7] databases).
The role of impulsivity in this correlation is important, given that impulsive behavior is common in adolescents with ADHD, pointing to a connection between ADHD and development of obesity, an idea consistent with our clinical observation that impulsive eating behaviors are common in adult and adolescent OB+ADHD patients.
The availability of extensive genome sequence data and advances in structure determination over recent years allow the successful application of comparative genomics, sequence and structure comparisons to identify any such folds that may be somewhat less widely represented than the OB or SH3-like folds.
A few ancient and widespread β-rich folds such as the SH3-like barrel and the OB fold appear to have colonized multiple functional niches early in evolution, although their earliest versions may have had roles related to RNA metabolism [ 9, 11, 12, 13].
A DALI search [ 20] of the PDB database with this β-barrel revealed no specific structural relationships with other folds such as the OB fold or the SH3-like barrel beyond the presence of curved β-sheets, suggesting that it represents a domain with a distinct fold (Figure 2).
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