Words similar to nullmice

Example sentences for: nullmice

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In cell cultures of CD4 T cells and B cells from allergic individuals, addition of anti-CD81 antibody enhances IL-4 production from the T cells [ 19 ] . In mice, either complete lack of CD81, or lack of CD81 on B cells, leads to impaired humoral and Th2 immune responses [ 20 21 ] . Allergen-induced airway hyperresponsiveness is also decreased in CD81 nullmice [ 22 ] . Finally, lack of CD81 on murine T cells diminishes IL-4 production, with reduced expression of ICOS, GATA-3, STAT6 and phosphorylated STAT6 [ 23 ] .
Using CD81 nullmice, CD81 was found to be required for effective Th2, but not Th1, immune responses [ 20 21 22 23 ] . But CD81 has also been found to generally costimulate T cell responses in mouse [ 16 ] and human [ 17 ] . Thus, the costimulation of T cell cytokine production by CD81 need not necessarily be biased towards Th2 cytokines.