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Example sentences for: ntds

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NTDs are second only to congenital heart defects as a cause of perinatal mortality due to birth defect and range in incidence from 0.5 to 12 per 1000 live births, depending on the country, accounting for 400,000 births world-wide annually.
Further support for the contention that VA may produce NTDs by way of GABA activity include the following evidence.
Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
Factors that predispose individuals to NTDs are numerous.
Socio-economic status, genetic factors, maternal illness and maternal drug exposure are important contributors to the risk of NTDs.