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Example sentences for: ntds

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Drug models of NTDs are valued because the drug's action provides a possible explanation of the pathophysiology of NTDs.
Further support for the contention that VA may produce NTDs by way of GABA activity include the following evidence.
Socio-economic status, genetic factors, maternal illness and maternal drug exposure are important contributors to the risk of NTDs.
Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
Factors that predispose individuals to NTDs are numerous.