Words similar to normalizations
Example sentences for: normalizations
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The third assumption is important for signal-dependent normalizations and is supported by the intuition that genes with 100 to 1,000 mRNA copies per cell will be no more or less biased toward up- or downregulation than genes with 10,000 to 100,000 copies per cell.
Additional data files showing MA plots and signal distributions from all the HIV, glnA, tnrAarrays for the different normalizations are available with the online version of this paper and at [ 17].
All these techniques are inherently linear; there have been recent reports of nonlinear normalizations for cDNA [ 12], oligonucleotide [ 13, 14] and other [ 15] arrays.
In addition, a pair of dye-swapped replicate arrays from A. thaliana were also normalized to investigate the various normalizations methods versus dye-swap normalization.
The dye bias can clearly be seen in the unnormalized Cy3 and Cy5 signal distributions shown in green and red respectively in Figure 2. Both global and scaled print-tip lowess and qspline normalizations showed similar signal-distribution comparisons.