Words similar to nonsynonymous

Example sentences for: nonsynonymous

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When-in house sequencing was done to verify nonsynonymous changes found in the in silico alignment, a minimum of two forward reads and two reverse reads was run for each sample of PCR products.
In particular, rates of nonsynonymous substitution per site (resulting in an amino acid change; d N ) often greatly exceed those of synonymous substitution per site (silent change; d S ), as expected if most mutations are fixed because they increase fitness (Figure 1).
The plot of the ratio of synonymous/nonsynonymous substitutions (dS/dN) identified five regions where the synonymous substitution rate exceeds the nonsynonymous substitution rate (dS / dN > 1), suggesting that homology in these areas was driven by the need for AA conservation (Figure 2b).
451; r 2= 0.553), suggesting that the base composition of nonsynonymous sites in LTG is mainly the result of mutational pressures, and hence that their amino-acid composition is exceptionally affected by the constraints acting on the nucleotide sequence.
The strength of the selection on a given gene relative to the mutation pressure can be estimated by the method of the relative neutrality plot (RNP), which gives indications on how 'neutral' a coding sequence can be considered [ 18 19 ] . The method consists of plotting the G+C content at the constrained (or nonsynonymous) positions (that is, first and second positions) of the codons against the G+C content at the relaxed (or synonymous) position (that is, third position).