Words similar to nonsynonymous

Example sentences for: nonsynonymous

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Selection was measured in terms of the ratio of the rate of nonsynonymous substitutions (K n ), which are usually subject to selective pressure, to the rate of synonymous substitutions (K s ), which are assumed to be (nearly) neutral.
451; r 2= 0.553), suggesting that the base composition of nonsynonymous sites in LTG is mainly the result of mutational pressures, and hence that their amino-acid composition is exceptionally affected by the constraints acting on the nucleotide sequence.
The number of synonymous nucleotide substitutions per synonymous site (K s ), and the number of nonsynonymous nucleotide substitutions per nonsynonymous site (K n ) were estimatedusing the Pamilo-Bianchi-Li method [ 80, 81].
In particular, rates of nonsynonymous substitution per site (resulting in an amino acid change; d N ) often greatly exceed those of synonymous substitution per site (silent change; d S ), as expected if most mutations are fixed because they increase fitness (Figure 1).
The strength of the selection on a given gene relative to the mutation pressure can be estimated by the method of the relative neutrality plot (RNP), which gives indications on how 'neutral' a coding sequence can be considered [ 18 19 ] . The method consists of plotting the G+C content at the constrained (or nonsynonymous) positions (that is, first and second positions) of the codons against the G+C content at the relaxed (or synonymous) position (that is, third position).