Words similar to nonsynonymous

Example sentences for: nonsynonymous

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Using a codon-based alignment of the NA sequences in the high homology group, we analyzed the occurrence of synonymous and nonsynonymous substitutions over the entire coding region.
451; r 2= 0.553), suggesting that the base composition of nonsynonymous sites in LTG is mainly the result of mutational pressures, and hence that their amino-acid composition is exceptionally affected by the constraints acting on the nucleotide sequence.
In particular, rates of nonsynonymous substitution per site (resulting in an amino acid change; d N ) often greatly exceed those of synonymous substitution per site (silent change; d S ), as expected if most mutations are fixed because they increase fitness (Figure 1).
The number of synonymous nucleotide substitutions per synonymous site (K s ), and the number of nonsynonymous nucleotide substitutions per nonsynonymous site (K n ) were estimatedusing the Pamilo-Bianchi-Li method [ 80, 81].
Of the nonsynonymous changes that we identified by multiple alignment of BLAST hits and verified by in-house sequencing, fewer than half are listed in the SNP database.