Words similar to nonfunctional
Example sentences for: nonfunctional
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As we stated earlier, the absence of stress fibers in the A549 cell suggests that stress fibers per se are not essential for RSV growth either, and that one or more steps of the Virus (F) → RhoA → profilin → actin signaling pathway is perhaps missing or nonfunctional in A549.
The stable loss of expression of CD26, a T-cell activation marker, in MF/SS suggests that this activation pathway may be nonfunctional in most MF/SS tumors.
Given a multiple sequence alignment of orthologous sequences from closely related species, the aligned and invariant regions should be enriched for functionally important residues [ 12 13 ] . Additional Saccharomyces genomes were sequenced to ensure sufficient sequence similarity to S. cerevisiae such that orthologous regions could be reliably aligned, yet enough sequence divergence that functional sequences would be much more conserved than nonfunctional sequences [ 26 28 ] . To confirm that regulatory sequences were found in conserved regions, we tested a database of 47 known, nonredundant regulatory motifs and found that 35 show conservation ratios that were more than three standard deviations above that expected by chance [ 26 29 ] .
The biological significance of this exon is therefore unclear and, in all likelihood, its inclusion in the mRNA leads to the formation of a nonfunctional protein.
This lack of response may be attributed, at least in part, to the presence of nonfunctional hERα as determined by the inability of hERα to bind hormone, to recognize and bind to specific DNA-responsive elements and/or its inability to recruit other transcriptional activation factors [ 6 11 12 ] . It may also be attributed to tumor heterogeneity in which some tumor cells may continue to express functional hERα while other cells may express either dysfunctional hERα or do not express hERα at all.
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