Words similar to nonfunctional

Example sentences for: nonfunctional

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Except for a bias to VH4, a similar overall proportion of nonfunctional rearrangements was seen in the peripheral blood of healthy donors using single-cell PCR of genomic DNA [ 9].
They showed that the splice site at the 3' end of exon 7 was mutated from TAG GTATGT to TAG GTGTTG (where underlined sequence is the 3' end of exon 7 and ETn insertion sequence is in bold) and predicted that this site would be nonfunctional, thereby abolishing splicing of exon 7 to exon 8. They proposed that the T Wis allele would produce a transcript comprised of exons 1 through 7 followed by read-through transcription of the ETn element, resulting in a modified C-terminal end, or alternatively, that upstream splice donor sites would be used, shortening the transcript and protein product.
Thus, loss of nmt55/p54 nrbprotein or the expression of nmt55/p54 nrbprotein variants in tumor cells may result in the loss of hERα expression, the expression of nonfunctional hERα or the altered expression other critical cell growth factors due to lack of proper pre-mRNA splicing.
The biological significance of this exon is therefore unclear and, in all likelihood, its inclusion in the mRNA leads to the formation of a nonfunctional protein.
Out of 14 distinct VH1-DH-JH sequences, 2 were nonfunctional (14%).