Words similar to nonfunctional
Example sentences for: nonfunctional
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This lack of response may be attributed, at least in part, to the presence of nonfunctional hERα as determined by the inability of hERα to bind hormone, to recognize and bind to specific DNA-responsive elements and/or its inability to recruit other transcriptional activation factors [ 6 11 12 ] . It may also be attributed to tumor heterogeneity in which some tumor cells may continue to express functional hERα while other cells may express either dysfunctional hERα or do not express hERα at all.
The stable loss of expression of CD26, a T-cell activation marker, in MF/SS suggests that this activation pathway may be nonfunctional in most MF/SS tumors.
They showed that the splice site at the 3' end of exon 7 was mutated from TAG GTATGT to TAG GTGTTG (where underlined sequence is the 3' end of exon 7 and ETn insertion sequence is in bold) and predicted that this site would be nonfunctional, thereby abolishing splicing of exon 7 to exon 8. They proposed that the T Wis allele would produce a transcript comprised of exons 1 through 7 followed by read-through transcription of the ETn element, resulting in a modified C-terminal end, or alternatively, that upstream splice donor sites would be used, shortening the transcript and protein product.
7), suggesting that the signaling pathway that leads to stress fiber formation is missing or nonfunctional in A549 cells.
Given a multiple sequence alignment of orthologous sequences from closely related species, the aligned and invariant regions should be enriched for functionally important residues [ 12 13 ] . Additional Saccharomyces genomes were sequenced to ensure sufficient sequence similarity to S. cerevisiae such that orthologous regions could be reliably aligned, yet enough sequence divergence that functional sequences would be much more conserved than nonfunctional sequences [ 26 28 ] . To confirm that regulatory sequences were found in conserved regions, we tested a database of 47 known, nonredundant regulatory motifs and found that 35 show conservation ratios that were more than three standard deviations above that expected by chance [ 26 29 ] .
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