Words similar to nondisjunction
Example sentences for: nondisjunction
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However, only about 50% of diploid meiotic products from rec12-D15 (null) mutant meioses were heterozygous for centromere linked markers (Figure 5E), indicating that some fraction of the products were derived from precocious separation of sister chromatids (PSS) and/or MII nondisjunction (Figure 5C, 5D).
Thus, those meioses did not exhibit simple MI nondisjunction, because 100% of diploids arising from MI nondisjunction would be heterozygous at the centromeres (Figure 5B).
In the absence of crossover recombination (chiasmata) and a backup distributive (achiasmatic) system for chromosome segregation, MI nondisjunction should occur and 100% of any resulting diploid spore colonies would be heterozygous for centromere linked markers (Figure 5B).
Although they exhibit a striking difference in their apparent MI nondisjunction frequencies, the rec12-D15 (null) and rec12-Y98F (active site) mutants manifest at most a two-fold difference in the absolute frequency of meiotic diploids exhibiting MII missegregation patterns (Figures 4, 5, Table 2).
First, Rec12 may be required for an "MI nondisjunction checkpoint" that delays meiotic cells in which proper MI disjunction has failed to occur.