Words similar to noncanonical

Example sentences for: noncanonical

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Previous reports of ectopic expression of different Wnts in C57mg cells demonstrated Wnt-1 to be highly transforming whereas Wnt-5a failed to induce transformation [ 15 16 ] . By identifying downstream targets of Wnt-5a and Rfz-2, we wanted to determine which genes are responsible for these phenotypic changes as well as which genes might be targets of noncanonical Wnt signaling.
Such noncanonical structures may not be restricted to oligodeoxyribonucleotide arrays.
Previously identified genes regulated by Wnt signaling in this list include fibronectin [ 17 ] , IL-6 [ 18 ] , BMP-4 [ 19 ] , groucho related protein [ 20 ] , and Krox-20 [ 21 22 ] . Since Wnt-5a may couple to more than one frizzled receptor, different Wnt signaling pathways may be activated by Wnt-5a depending on the endogenous expression of various frizzled receptors [ 6 10 ] . Thus, it is possible that the gene expression pattern we identified may be due to the activation of both canonical and noncanonical Wnt signaling pathways.
We overexpressed Rfz-2 in addition to Wnt-5a in C57mg cells in order to augment the activation of noncanonical Wnt signaling.
In addition, other plant miRNAs may proceed through precursors of noncanonical structure, such as multiple stem-loops or stem-loops of poor quality [ 14 ] . The existence of these types of pre-miRNAs in metazoans is unknown at present.