Words similar to nonadherence
Example sentences for: nonadherence
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Study-defined criteria for therapy failure of a previously suppressive regimen were met by 4/21 patients in the continuous therapy/single interruption arm (patients S37, S47, S52, and S59) in association with self-reported nonadherence to therapy and detection of resistance mutations in phase I, as listed in Table 2. One patient in the repeated interruptions arm (1/21; patient S56) failed therapy after 20 wk following the third TI by maintaining a viral load between 50 and 999 copies/ml in the presence of previously undetected resistance mutations.
On a more conjectural level, the observed connection between decreased perception of health risk from nonadherence and over-reporting of adherence may indicate that health belief models that posit a direct relationship between perceived risk and adherence may also apply to the accurate recollection of past medication use [ 22 23 24 25 ] . In addition, the association with lower household income in our study population may indicate that a more stressful if not disorganized life situation, as suggested by lower socioeconomic status, may increase the likelihood of inaccurately believing that missed doses were taken.
Average nonadherence was 16% among individuals who reported that they were nonadherent <1 day a week compared with 40% among individuals who reported more frequent nonadherence.
The findings suggest that factors related to socioeconomic status, the dosing regimen, and perceived risk from nonadherence may influence how accurately patients recall and report their adherence.
While only 21% of participants acknowledged missing doses one or more days per week, electronic medication monitoring documented nonadherence at this or greater levels in 42% of participants.
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