Words similar to nonadherence
Example sentences for: nonadherence
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Study-defined criteria for therapy failure of a previously suppressive regimen were met by 4/21 patients in the continuous therapy/single interruption arm (patients S37, S47, S52, and S59) in association with self-reported nonadherence to therapy and detection of resistance mutations in phase I, as listed in Table 2. One patient in the repeated interruptions arm (1/21; patient S56) failed therapy after 20 wk following the third TI by maintaining a viral load between 50 and 999 copies/ml in the presence of previously undetected resistance mutations.
Although studies have been conducted to identify risk factors for nonadherence itself [ 16 ] , to the best of our knowledge, only one previous study has examined possible risk factors for over-reporting of adherence [ 17 ] . None has utilized electronic medication monitors to study this area involving antihypertensive medications.
Average nonadherence was 16% among individuals who reported that they were nonadherent <1 day a week compared with 40% among individuals who reported more frequent nonadherence.
Following reinitiation of therapy after phase II, patients suppressed viral replication to less than 50 copies/ml by a median time of 10 (6–12) wk in both arms, excluding for two patients in the continuous therapy/single interruption arm who elected to stay off ART indefinitely and one patient from the repeated interruptions arm who reported nonadherence following regimen reinitiation yet reached 52 copies/ml before withdrawing from additional follow-up.
The findings suggest that factors related to socioeconomic status, the dosing regimen, and perceived risk from nonadherence may influence how accurately patients recall and report their adherence.
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