Words similar to nonadherence
Example sentences for: nonadherence
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Following reinitiation of therapy after phase II, patients suppressed viral replication to less than 50 copies/ml by a median time of 10 (6–12) wk in both arms, excluding for two patients in the continuous therapy/single interruption arm who elected to stay off ART indefinitely and one patient from the repeated interruptions arm who reported nonadherence following regimen reinitiation yet reached 52 copies/ml before withdrawing from additional follow-up.
Although studies have been conducted to identify risk factors for nonadherence itself [ 16 ] , to the best of our knowledge, only one previous study has examined possible risk factors for over-reporting of adherence [ 17 ] . None has utilized electronic medication monitors to study this area involving antihypertensive medications.
Numerous adverse clinical outcomes have been linked to nonadherence including loss of blood pressure control [ 1 2 ] , acute cardiac events [ 3 ] , renal transplant rejection [ 4 ] , seizures [ 5 ] , and elevated Human Immunodeficiency Virus RNA levels [ 6 ] . Efforts to enhance medicinal adherence have met with varying levels of success [ 7 8 9 ] .
While only 21% of participants acknowledged missing doses one or more days per week, electronic medication monitoring documented nonadherence at this or greater levels in 42% of participants.
Study-defined criteria for therapy failure of a previously suppressive regimen were met by 4/21 patients in the continuous therapy/single interruption arm (patients S37, S47, S52, and S59) in association with self-reported nonadherence to therapy and detection of resistance mutations in phase I, as listed in Table 2. One patient in the repeated interruptions arm (1/21; patient S56) failed therapy after 20 wk following the third TI by maintaining a viral load between 50 and 999 copies/ml in the presence of previously undetected resistance mutations.
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