Words similar to non-viable
Example sentences for: non-viable
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(The fraction of neutral mutants at distance d is equivalent to w ( d ) under the assumption that mutant sequences which fold into the same structure as the reference sequence have fitness 1, and all other mutants have fitness 0.) In addition, to distinguish neutral from compensatory mutations, we recorded at each Hamming distance d , for all viable sequences as well as a random sample of up to 1,000 non-viable sequences, the average number of viable sequences after an additional one-step mutation.
Consider the fitness landscape depicted in Figure 2, in which circles represent viable sequences while crosses are non-viable ones.
This contribution is given by [1 - γ ( d )] w ( d ) x neut ( d ). We must then obtain the contribution of additional compensatory mutations at distance d + 1. These are given by 1 - w ( d ), the number of non-viable sequences at distance d , multiplied by the probability with which these non-viables turn into viable sequences after a single mutation, x comp ( d ). Hence, we arrive at
In an attempt to determine if increased survival of the antisense cells was do to increased proliferation of the antisense cells or decreased death rate, the number of trypan blue positive, non-viable were examined after 14 days without estrogen.
In the following analyses, we denote the average fraction of viable sequences that are one mutation away from a viable sequence at distance d as x neut ( d ). Similarly, we denote as x comp ( d ) the average fraction of viable sequences that are one mutation away from a non-viable sequence at distance d .
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