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Example sentences for: non-viable
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(The fraction of neutral mutants at distance d is equivalent to w ( d ) under the assumption that mutant sequences which fold into the same structure as the reference sequence have fitness 1, and all other mutants have fitness 0.) In addition, to distinguish neutral from compensatory mutations, we recorded at each Hamming distance d , for all viable sequences as well as a random sample of up to 1,000 non-viable sequences, the average number of viable sequences after an additional one-step mutation.
In the following analyses, we denote the average fraction of viable sequences that are one mutation away from a viable sequence at distance d as x neut ( d ). Similarly, we denote as x comp ( d ) the average fraction of viable sequences that are one mutation away from a non-viable sequence at distance d .
In an attempt to determine if increased survival of the antisense cells was do to increased proliferation of the antisense cells or decreased death rate, the number of trypan blue positive, non-viable were examined after 14 days without estrogen.
This contribution is given by [1 - γ ( d )] w ( d ) x neut ( d ). We must then obtain the contribution of additional compensatory mutations at distance d + 1. These are given by 1 - w ( d ), the number of non-viable sequences at distance d , multiplied by the probability with which these non-viables turn into viable sequences after a single mutation, x comp ( d ). Hence, we arrive at
In this system, the secondary structure of an RNA molecule is taken as a predictor of the fitness of the underlying sequence [ 31 32 33 34 35 36 ] . RNA folding has the advantage that all genotypes can be separated naturally into only two classes, the viable ones (those that fold into a particular target structure) with fitness 1, and the non-viable ones (those that fail to fold into that exact structure), which are assigned fitness 0. Such a classification permits a precise mathematical analysis, while at the same time many important properties of high-dimensional fitness landscapes are retained [ 37 ] . The set of all viable sequences can be decomposed into smaller sets called neutral networks [ 38 39 ] . Two viable sequences belong to the same neutral network if one sequence can be transformed into the other through a series of single point mutations, without passing through a sequence with lower fitness along the way.
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