Words similar to non-tumorigenic
Example sentences for: non-tumorigenic
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Stimulation of RAR α and γ mRNA in LNCaP cells by T differed from that in normal rat prostate and non-tumorigenic rat prostate epithelial cells (NRP-152), but was comparable to that in tumorigenic rat prostate epithelial cells (NRP-154) [ 13 14 ] . In cervical carcinoma cells, the RAR β gene was abnormally down-regulated by RA [ 36 ] . In ER positive human breast cancer cells, RAR α mRNA was also up-regulated by estrogen [ 16 ] . Thus, T stimulation of RAR mRNAs in LNCaP cells could be related to the pathologic state of the cells.
STAT1, another signaling intermediate in the IL-6 pathway, has been observed to be activated in non-tumorigenic cells, and may function as a "check" for STAT3 phosphorylation, a possible oncogenic event [ 30 31 ] . We are investigating whether or not STAT1 is phosphorylated by JAK2 in NRP-152 cells, and whether STAT1 phosphorylation is required for the survival of NRP-152 cells.
The tumorigenic (NRP-154) and non-tumorigenic (NRP-152) rat prostate epithelial cell lines were the gift of Dr. David Danielpour, Ireland Cancer Center, University Hospital of Cleveland, Case Western Reserve University, Cleveland, OH [ 23 ] . NRP-152 cells were propagated in DMEM/ Ham's F12 medium (1:1; GIBCO) supplemented with 10% fetal bovine serum (GIBCO), 2 mM glutamine (GIBCO), epidermal growth factor (20 ng/ml), insulin (5 μg/ml), dexamethasone (0.
The tumorigenic line NRP-154 expressed phospho-STAT3 under normal growth condition, while the non-tumorigenic line did not.
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that mediate the action of retinoids [ 11 12 ] . We have demonstrated that in the rat, castration resulted in an increase in mRNAs for RAR α and γ in the prostate; such effects were prevented by T replacement [ 13 ] . We also demonstrated that the levels of mRNAs for RAR α and γ in non-tumorigenic rat epithelial cells (NRP152) were down-regulated, whereas those in tumorigenic cells (NRP154) were unaffected or up-regulated following T treatment [ 14 ] . In addition, RAR α was over-expressed in tumorigenic NRP154 cells.
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