Example sentences for: non-structural

How can you use “non-structural” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Previously we have reported the successful construction of several dengue virus replicons which replicate intracellularly without the pre-M and E proteins required to form infectious virions, including one replicon which can be expressed from transfected DNA [ 12 ] . Towards the goal of devising a "live" dual vaccine based on only non-structural dengue proteins and heterologous HIV material, we report here that these replicons can be harnessed to express heterologous genes, including HIV gp160 and gp120.

  • Finally, by eliciting an immune reaction against the dengue non-structural proteins remaining in replicons, dengue virus replicons may induce a protective immunity against dengue which would not predispose vaccinated individuals to DHF.

  • The non-structural proteins, NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 include an RNA-directed RNA polymerase and a protease function involved in cleaving certain positions of the long viral polyprotein which contains all the viral genes [ 23 24 ] . The four serotypes of dengue virus ("1" through "4") share approximately 60%-74% amino acid residue identity with one another in the E gene [ 25 ] and induce cross-reacting antibodies [ 26 ] .

  • However, we have previously argued that the replication of dengue replicons could not take place in the absence of the essential non-structural gene, NS1, which implies that NS1 is being made.


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