Words similar to non-selective
Example sentences for: non-selective
How can you use “non-selective” in a sentence? Here are some example sentences to help you improve your vocabulary:
They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.
We studied two dosages (pharmacologicaland non-pharmacological) as a difference in dose-dependency forcardiac function improvement has previously been demonstrated byus with another non-selective beta-blocker [ 18 ] .Furthermore, we wanted to determine if carvedilol might exert beneficialeffects independent of heart rate effects.
He says we should close the gap between selective colleges and non-selective ones.
Clomipramine is a non-selective re-uptake inhibitor of serotonin, and to some extent norepinephrine [ 21 ] and fluoxetine is a selective serotonin re-uptake inhibitor [ 22 ] . Both of these drugs have proven to be effective in different animals models of OCD [ 23 ] . As an additional control, hamsters were also treated with desipramine, a noradrenergic re-uptake inhibitor [ 24 ] that has been found ineffective in inhibiting OCD in preclinical [ 25 ] and clinical studies [ 26 27 ] .
Another class of compounds known as imidazoles, of which SKF 96365 is the best studied, have also been shown to block MTX-induced responses in many cell types [ 5 7 12 28 ] . The imidazoles, which are antifungal agents that inhibit cytochrome P 450 , are relatively non-selective and are known to block voltage-gated Ca 2+channels and receptor-activated Ca 2+influx through so-called store-operated channels (SOCs) [ 29 ] , but their mechanism of action in this regard remains unknown.
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