Words similar to non-selective
Example sentences for: non-selective
How can you use “non-selective” in a sentence? Here are some example sentences to help you improve your vocabulary:
Another class of compounds known as imidazoles, of which SKF 96365 is the best studied, have also been shown to block MTX-induced responses in many cell types [ 5 7 12 28 ] . The imidazoles, which are antifungal agents that inhibit cytochrome P 450 , are relatively non-selective and are known to block voltage-gated Ca 2+channels and receptor-activated Ca 2+influx through so-called store-operated channels (SOCs) [ 29 ] , but their mechanism of action in this regard remains unknown.
The initial MTX-induced increase in [Ca 2+] i reflects the activation of a Ca 2+-permeable non-selective cation channel (CaNSC) [ 1 4 5 6 7 8 ] . This channel, which has a reported conductance in the range of 12-40 pS depending on ionic conditions [ 5 9 10 11 ] , causes rapid membrane depolarization, which in excitable cells, leads to activation of voltage-sensitive channels.
In a recent paper by Laine [ 33 ] , it was calculated that although COX2 inhibitors reduced the incidence of gastrointestinal damage when compared to non-selective COX inhibitors, these benefits were achieved at a significant increase in health care costs (approximately $560 per patient per year).
It has also been reported that inhibition of endothelial nitric oxide synthases (using the non-selective NOS inhibitor L-NAME), induces endothelial adhesion molecules (ICAM-1 and VCAM-1) in HUVEC [ 24, 25].
As noted earlier, fluoxetine is a selective serotonin re-uptake inhibitor while clomipramine is a non-selective re-uptake inhibitor of serotonin, and to some extent norepinephrine.
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