Words similar to non-selective
Example sentences for: non-selective
How can you use “non-selective” in a sentence? Here are some example sentences to help you improve your vocabulary:
In conclusion, our model of heart failure, which shows a highlevel of congruence with the human condition, has been shown tohave a high level of apoptosis that corresponds with cardiac failure.Carvedilol, a non-selective β-blocker with α-blocking propertiesas well as antioxidant properties, significantly reduced the incidenceof programmed cell death while improving cardiac function.
This occurs, not by release of Ca 2+from internal stores, but rather from activation of a ubiquitously-expressed, non-selective, Ca 2+-permeable cation channel (CaNSC), present in the plasmalemma [ 2, 3, 4, 5, 6, 7, 8].
Another class of compounds known as imidazoles, of which SKF 96365 is the best studied, have also been shown to block MTX-induced responses in many cell types [ 5 7 12 28 ] . The imidazoles, which are antifungal agents that inhibit cytochrome P 450 , are relatively non-selective and are known to block voltage-gated Ca 2+channels and receptor-activated Ca 2+influx through so-called store-operated channels (SOCs) [ 29 ] , but their mechanism of action in this regard remains unknown.
They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.
Then 500 cells were plated onto selective and non-selective (EMM+uracil) plates to determine the fraction of cells containing plasmid.
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