Words similar to non-selective
Example sentences for: non-selective
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4B) shifted from approximately -24 mV in the initial state to about -4 mV in the activated state, consistent with the activation of a non-selective cationic conductance permeable to both Na +and K +. Similar results were observed for other SNP-activated oocytes (n = 5), as well as for AQP1-expressing oocytes activated by prior incubation in 10 mM 8Br-cGMP (as described in [ 11 ] ). In AQP1-expressing oocytes, the conductance induced by 8Br-cGMP in control Na +saline did not change significantly [(+) 11.
We studied two dosages (pharmacologicaland non-pharmacological) as a difference in dose-dependency forcardiac function improvement has previously been demonstrated byus with another non-selective beta-blocker [ 18 ] .Furthermore, we wanted to determine if carvedilol might exert beneficialeffects independent of heart rate effects.
They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.
In contrast, we have reported that cat's claw prevents the significant enteropathy associated with sustained use of indomethacin, a non-selective COX inhibitor [ 23 ] , and this combination could alleviate the gastrointestinal damage without the high costs of COX2 inhibitors.
In conclusion, our model of heart failure, which shows a highlevel of congruence with the human condition, has been shown tohave a high level of apoptosis that corresponds with cardiac failure.Carvedilol, a non-selective β-blocker with α-blocking propertiesas well as antioxidant properties, significantly reduced the incidenceof programmed cell death while improving cardiac function.
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