Words similar to non-selective
Example sentences for: non-selective
How can you use “non-selective” in a sentence? Here are some example sentences to help you improve your vocabulary:
In contrast, we have reported that cat's claw prevents the significant enteropathy associated with sustained use of indomethacin, a non-selective COX inhibitor [ 23 ] , and this combination could alleviate the gastrointestinal damage without the high costs of COX2 inhibitors.
They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.
In a recent paper by Laine [ 33 ] , it was calculated that although COX2 inhibitors reduced the incidence of gastrointestinal damage when compared to non-selective COX inhibitors, these benefits were achieved at a significant increase in health care costs (approximately $560 per patient per year).
We studied two dosages (pharmacologicaland non-pharmacological) as a difference in dose-dependency forcardiac function improvement has previously been demonstrated byus with another non-selective beta-blocker [ 18 ] .Furthermore, we wanted to determine if carvedilol might exert beneficialeffects independent of heart rate effects.
In order to test this hypothesis, the activation profiles of a set of non-selective opioid ligands need to be assessed in vitro , followed by in vivo evaluation of analgesic and unwanted effects.
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