Words similar to non-canonical
Example sentences for: non-canonical
How can you use “non-canonical” in a sentence? Here are some example sentences to help you improve your vocabulary:
Wnts in this class have been shown to signal in a non-canonical Wnt signaling pathway, the Wnt/Ca 2+pathway (Wnt-5a, -4, -11).
An inhibitory effect of USF on Myc-mediated cellular proliferation has been demonstrated in HeLa cells [ 33 ] , and a non-canonical HLH element inhibits expression of the fibroblast growth factor binding protein (FGF-BP) in several carcinoma cells [ 34 ] . Furthermore, USF2 inhibits binding of hypoxia-inducible factor-1 (HIF-1) to the plasminogen activator inhibitor -1 (PAI-1) gene in hepatocytes in order to disturb transcriptional activation [ 35 ] . Our results add C/EBPβ-mediated activation of RIIβ to the mechanisms inhibited by USF.
These include any non-canonical base pair (not a G:C, A:U, or G:U; e.g., U:U), lone or single base pairs (when both positions in a base pair are not flanked by two nucleotides that are base paired to one another), base pairs in a pseudoknot arrangement, and base triples (a single nucleotide interacting with a base pair).
In considering these issues, it is of interest to note that in the early C. elegans embryo, Wnt signaling proceeds through a non-canonical pathway, through phosphorylation of the TCF homolog but not using the increase in β-catenin [ 33 ] . Cell divisions and polarization in the worm embryo occur on a time scale of minutes, and the different mechanism of Wnt signaling in that context may be more suitable than the inherently slower translation-dependent β-catenin increase.
Additionally, they state that a G:U wobble pair above the branch-point is also a determinant, which fits in with the observation that a non-canonical pair (A:A or A:C) is found at this position in some of the revertants.
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