Words similar to non-antigen-specific

Example sentences for: non-antigen-specific

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However, recent studies have indicated that large numbers of virus-specific CD8 +T cells preferentially accumulate in the synovial fluid of RA patients and that these cells are also oligoclonal, suggesting that non-antigen-specific homing may be responsible for the observed oligoclonality of CD8 +T cells in the synovial fluid [ 6 ] . Because chemokines such as macrophage inflammatory protein-1α and RANTES (regulated upon activation, normal T-cell expressed and secreted) are expressed in RA synovial tissue [ 7 8 ] , subsets of CD8 +T cells may be preferentially recruited into the synovial tissue in a non-antigen-specific manner.
This accelerated differentiation may be due to a non-antigen-specific effect in RA that differentiates all peripheral T cells irrespective of their specificity, or it may actually reflect an antigen-specific expansion of T cells potentially driven by autoantigen.