Words similar to non-allelic
Example sentences for: non-allelic
How can you use “non-allelic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Likewise, Arabidopsis PAI2 and PAI3 genes that have been trans-methylated by the PAI1/PAI4 locus do not transfer their methylation status to naive singlet genes [ 12 ] . In fact, there are few well-documented cases for the non-allelic relay of trans-silencing ability [ 11 24 ] . Does this amount to an operational difference between allelic (paramutation) and non-allelic (trans-silencing) interactions, or does it simply reflect a lack of data?
These data suggest that the competence for trans-silencing may be transferred between non-allelic transgenes, reminiscent of the allelic transfer of epigenetic activity during paramutation.
In contrast, in the PAI gene family, combining the master locus (WS ecotype PAI1/PAI4 ) with a non-allelic singlet target locus possessing 100% sequence identity (Columbia PAI2 ) resulted in methylation after two generations of heterozygous contact, and methylation became more pronounced after another two generations [ 12 ] . Likewise, in the petunia CHS gene family, interaction between an epiallele of the direct-repeat locus, CHS41, with two types of target loci, either an unlinked inverted repeat locus or a more naïve allele of CHS41, was initially additive and only became suppressive in the second generation [ 4 10 ] .
Here, combining a master locus (C73) with a non-allelic singlet locus possessing 100% sequence identity (L91) resulted in immediate trans-silencing, as seen by a reduction of GFP-COP1 expression and block of cosuppression, which was stably maintained in the presence or absence of the master locus.
Paramutation has been studied extensively for four maize loci that encode transcriptional regulators of pigment biosynthesis [ 1 ] . Paramutation has also been investigated in the Arabidopsis PAI gene family, at the a1 and chalcone synthase (CHS) transgene loci in petunia, and in a number of other cases [ 2 3 4 ] . The Arabidopsis resistance gene BAL/CPR1 displays a related form of epigenetic instability [ 5 6 ] . Interactions resembling paramutation also occur among non-allelic transgene loci with DNA sequence homology.
Loading...