Words similar to node-negative
Example sentences for: node-negative
How can you use “node-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:
Measuring loss of heterozygosity, O'Connell et al . [ 27 ] found that the majority of lymph node-negative primary breast tumors did not amplify a region linked to D14S62 and D14S51, while lymph node-positive breast tumors retained heterozygosity for these markers.
However, recurrence and death also occur in patients with node-negative breast cancer (NNBC).
By applying in situ hybridization, Tuck and colleagues identified breast tumor cells as a source of OPN [ 13 ] . Using a semiquantitative scoring system to evaluate immunohistochemical staining, these investigators found a correlation between OPN positivity (defined as >33% of tumor cells in a section staining for OPN) in lymph node-negative primary breast carcinomas and patient survival, suggesting that tumor cells with elevated OPN levels may behave differently with regard to disease progression [ 13 ] . Another recent study showed immunohistochemically that while OPN protein is expressed weakly in normal breast tissue, OPN is expressed strongly (>50% tumor cell staining) in pregnant/lactating tissue and in the majority (66%) of breast carcinomas.
More importantly, its expression in histologically node-negative patients point to the need to search for node micrometastasis or involvement of the excision margins by tumor.
The construction of a panel of molecular genetic markers for identifying the 13% lymph node-negative mammary carcinomas that are prone to develop metastases [ 3 ] would be valuable in indicating those cases in need of early aggressive therapy.
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