Words similar to nnr

Example sentences for: nnr

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The problem is particularly acute for NNR viruses, which have large RNA genomes [ 8 9 ] . The 10-15 kb long RNA genomes of these viruses require specific sequences at the 5' and 3' termini for transcription and replication, and must be properly encapsidated by the nucleocapsid protein (N) in order to be recognized by the viral RdRP [ 15 16 ] . Thus, any recombinant technology must be able to faithfully reproduce these features of the genome.
As described earlier (in the beginning of the Results section), intracellular NNR viral replication generates both negative- and positive-strand full-length genomic RNA, each of which should find complementarity to the appropriate strand of the anti-F dsRNA.
Using two different RSV gene mRNAs as targets, and another NNR virus (VSV) as well as cellular mRNAs as controls, we show that synthetic dsRNA molecules are highly efficient and specific silencers of cytoplasmic RNA viral gene expression.
The overall steps of a NNR viral macromolecular synthesis in the infected cell are relevant for this paper, and are briefly described here [ 3 ] . The L protein is believed to encode the basic RNA polymerization function, and binds to the viral promoter at the 3' end of the genomic RNA to initiate transcription.
Since NNR viruses co-opt the cellular translation machinery, the interferon response thus causes severe inhibition of viral translation.