Words similar to nlpc

Example sentences for: nlpc

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By analogy with all other thiol proteases, in the NlpC/P60 superfamily peptidases the cysteine would act as the nucleophile that attacks the peptide bond, while the histidine acts in sequential steps as the base and then acid catalyst for the proton transfers [ 37].
Interestingly, the eukaryotic versions typified by the LRAT, their viral homologs and the bacterial forms typified by E. coli YaeF, while containing all the hallmark signatures of the NlpC/P60 catalytic domain, showed a reversal in the positions of the motifs with the conserved cysteine and the conserved histidine in their primary structures (Figures 1, 2).
This suggests that despite the absence of significant sequence similarity, the NlpC/P60 domain is likely to contain a structural core corresponding to the classical papain-like protease fold (Figure 2).
These observations, taken together, suggest that classical NlpC/P60-like peptidases, the LRAT-like permuted forms, and the divergent GSPS amidase domain-like proteins comprise a vast superfamily of enzymes with different biochemical activities.
Thus, in these proteins the central motif of the classic NlpC/P60 proteins with the conserved glycine was the most amino-terminal conserved motif, followed by the motif containing the conserved histidine, and then the one with the cysteine.