Words similar to nkb
Example sentences for: nkb
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Several studies have shown the distribution of NKA (preprotachykinin A mRNA) [ 12 ] and NKB (peptide-2; preprotachykinin B mRNA) [ 14 16 17 20 ] in the CNS of the rat.
Thus, the differences found in the distribution of both neuroactive substances in the human brainstem could be due to the intraneuronal segregation transport of the peptides and/or the different processing of the precursor [see [ 31 ] ]. Another possibility could be that the immunoreactivity observed in those nuclei of the human brainstem in which NK-ir structures, but not SP, are found is due to NKB (the antibody used here also recognizes NKB).
Thus, the anti-NKB antibody (IHC 7357) showed the following crossreactivities: 100% for NKB, 2% for physalaemin, 1% for eledoisin, 0.6% for kassinin, 0.2% for substance P, 0.1% for NKA and 0% for neuropeptide K. Moreover, in the nuclei of the human brainstem in which NKB was observed, the density of the immunoreactivity for NKB was lesser than that found in the same nuclei for NKA (see and compare Figs.
6B; 10A; 11A,11B), since the distribution of NKB is much less widespread in the human brainstem, in comparison with the distribution found for NKA(personal observation obtained after using a very specific rabbit anti-NKB antibody from Peninsula).
Our data are in agreement with previous results described in the rat brainstem, using radioimmunoassay techniques [ 29 30 ] . Thus, these latter authors found higher levels of NKA and lower levels of NKB in both the midbrain and the medulla oblongata of the rat [ 30 ] . In both regions of the human brainstem, we observed a high density of NK-ir structures.
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