Words similar to nkb
Example sentences for: nkb
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It is also known that the biological actions of NKA, NKB and SP are mediated by three receptors, named neurokinin (NK)-1, NK-2 and NK-3 [ 2 ] . Thus, the tachykinins have been implicated in several physiological actions such as salivation, the regulation of smooth muscle contraction, depolarization of central neurons, hyperactivity, interaction with dopaminergic A-10 neurons mediating behavioral activation, regulation of blood pressure, and the transmission of the baroreceptor reflex [ 3 4 5 6 7 ] . In addition, a loss of tachykinin-containing neurons has been described in neurodegenerative diseases [ 8 ] , suggesting that the decrease in the amount of tachykinins could be involved in these and other diseases [ 9 10 ] .
6B; 10A; 11A,11B), since the distribution of NKB is much less widespread in the human brainstem, in comparison with the distribution found for NKA(personal observation obtained after using a very specific rabbit anti-NKB antibody from Peninsula).
Our data are in agreement with previous results described in the rat brainstem, using radioimmunoassay techniques [ 29 30 ] . Thus, these latter authors found higher levels of NKA and lower levels of NKB in both the midbrain and the medulla oblongata of the rat [ 30 ] . In both regions of the human brainstem, we observed a high density of NK-ir structures.
Thus, the differences found in the distribution of both neuroactive substances in the human brainstem could be due to the intraneuronal segregation transport of the peptides and/or the different processing of the precursor [see [ 31 ] ]. Another possibility could be that the immunoreactivity observed in those nuclei of the human brainstem in which NK-ir structures, but not SP, are found is due to NKB (the antibody used here also recognizes NKB).
Thus, the antibody used, in the present work, principally recognizes NKA but shows some cross-reactivity with NKB.
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