Words similar to nitrotyrosine
Example sentences for: nitrotyrosine
How can you use “nitrotyrosine” in a sentence? Here are some example sentences to help you improve your vocabulary:
Additionally, it appears that the population sub-groups at greatest risk for gastric cancer have a limited ability to secrete ascorbic acid from the plasma through the mucosal and into the gastric lumen [ 30 ] . In a related study, supplementation with vitamin C reduces the degree of apoptosis and nitrotyrosine immunohistochemistry [ 13 ] , a marker of peroxynitrite formation [ 15 ] . NF-κB is activated in gastric epithelia with H. pylori infection, and clearance of this infection reduced NF-κB levels as well as expression of inducible nitric oxide [ 5 13 ] , thereby reducing the mucosal burden of nitric oxide and possibly peroxynitrite.
The first proposes that the mutated SOD1 interacts with NO to produce peroxynitrite (ONOO -), which damages proteins by modifying tyrosine to nitrotyrosine residues [ 42 43 44 ] . The second postulates that the mutant SOD1 possesses an enhanced peroxidase activity, which causes oxidative modification of nucleic acids, proteins and lipids [ 45 46 47 ] . Both of these activities require copper at the active center of SOD1.
The resultant nitrotyrosine is used as a marker of peroxynitrite or at least nitration reactions in gastritis [ 13 ] , inflammatory bowel disease [ 15 16 ] as well as general inflammation [ 17 ] . While we have demonstrated that peroxynitrite-induced apoptosis of macrophages and colon epithelial cells is reduced by ascorbic acid [ 18 ] , it is not known if other dietary antioxidants exert similar benefits or if they are present in epithelial cells from the upper gastrointestinal tract.
Previously, in Fabry disease, we have reported resting cerebral hyper-perfusion in a predominantly vertebro-basilar distribution together with abnormalities of vascular nitrotyrosine staining.
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