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Example sentences for: newkirk
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Newkirk et al . also observed that the frequency of autoantibodies to each of the antigens occurred more frequently among CMV seropositive subjects than among CMV seronegative subjects [ 14 ] . For CMV seropositive subjects, they observed that 42 (84%) subjects had antibodies to RNP, 32 (64%) had antibodies to Sm, and 23 (46%) had antibodies to U1-70 kD [ 14 ] . If Newkirk et al . used a negative/positive cutoff value of the mean plus three standard deviations then, overall, less than 10% of their sera contained autoantibodies.
To confirm the findings of Newkirk et al . [ 14 ] , we evaluated sera from individuals either naturally infected with CMV or immunized with the live attenuated Towne strain of CMV for the presence of antibodies to three antigens: Sm, RNP, and U1-70 kD.
In another study, Newkirk and coworkers also observed that a recombinant gB vaccine, which expressed the gB protein of the Towne vaccine, induced antibodies to CMV gB when administered to mice, suggesting that CMV gB induces antibodies crossreactive to U1-70 kD [ 13 ] . If this is the case, it predicts a correlation between levels of antibodies to gB and U1-70 kD in sera.
To detect antibodies to U1-70 kD, Newkirk et al . used only an EIA assay.
This HLA type occurs among 60% of patients with autoimmune disease and antibodies to U1-70 kD, but its prevalence in the normal healthy individuals is only about 25% [ 16 30 ] . Hence, if the association between HLA DR4 and the presence of antibodies to U1-70 kD exists for healthy individuals and if, due to selection bias, our population contained very few (<4%) DR4-positive individuals and the population of Newkirk et al . contained a very high (≥ 50%) prevalence of DR4-positive subjects, this could account for the observed differences.
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