Words similar to neuropathic
Example sentences for: neuropathic
How can you use “neuropathic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The transcriptional changes lead both to adaptive responses, such as the capacity to survive the injury and re-grow the injured axon, and maladaptive responses that can lead to a change in sensation, including the generation of neuropathic pain [ 3 4 ] .
Neurogranin has been shown to be phosphorylated by PKCγ, and this phosphorylation is greatly decreased in PKCγ knockout mice, suggesting neurogranin is a PKCγ-specific substrate [ 9 ] . Evidence that strongly suggests the phosphorylation of neurogranin plays an important role in neural plasticity comes from the studies that demonstrated neurogranin knockout mice show essentially the same deficits in behaviors related to learning and memory as that of the PKCγ knockout mice [ 10 ] . Neurogranin is not only a substrate of PKCγ, but also plays a important role in regulating PKC signaling [ 11 ] . Interstingly, PKCγ knockout mice demonstrate reduced neuropathic pain [ 12 ] . Similar to neurogranin, we found that a calmodulin-binding, vesicle-associated, CAM kinase IV-like protein is highly expressed and enriched in the superficial layer of the dorsal spinal cord.
Several of these changes are maladaptive in the sense that they contribute to the generation of the abnormal sensations that constitute neuropathic pain, by producing ectopic spontaneous activity into the CNS, altering synaptic drive, increasing excitability and diminishing inhibitory action in the dorsal horn of the spinal cord, and by making novel synaptic contacts with inappropriate neurons [ 1 4 ] . A number of the injury-regulated genes we describe here may contribute directly to this altered sensory processing; CB1 receptor, VGF, the phospholemman ion channel, SNAP25 A, endothelin-1 and the ligand-gated 5-HT3 receptor (Table 4, see additional file 3).
We then further characterized the cellular localization of a subset of these genes in the spinal cord, as well as the regulation of a subset of the genes in a neuropathic pain model.
Patients tend to describe neuropathic pain with words like burning, tingling, numbness, shooting, stabbing, or electric-like feelings.
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