Words similar to neurodegenerative
Example sentences for: neurodegenerative
How can you use “neurodegenerative” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is postulated that tissue injury by these reactive oxygen species accumulates over a long period of time and plays roles in the aging process and the development of heart disease, diabetes, chronic inflammatory diseases, cancer, and several neurodegenerative diseases (Halliwell 1999).
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
Estrogen deficiency has been implicated as a risk factor in the development of several neurodegenerative diseases [ 16, 17, 18] and estrogen replacement may result in improvement of cognitive function [ 19].
Recent studies on neurodegenerative diseases, including Parkinson's, Alzheimer's and prion diseases, suggest that it is not the long fibrils that produce toxicity and kill neurons, rather, it is the oligomeric aggregation intermediates that produce toxicity [ 54 55 ] . Interestingly, interactions between biomembranes and toxic proteins produce a dual effect of both promoting oligomeric aggregation of the proteins and membrane damage [ 56 57 58 59 ] , suggesting that one possible toxicity of oligomeric aggregates is mediated through damaging membranes.
In transfected cells, subdomains of TAF II 135 can act as dominant negative repressors of CREB activity [ [ 26 27 28 ] ]. It has further been suggested that some neurodegenerative diseases may result from sequestration of TAF II 135 by expanded polyglutamine domains and consequent interference with CREB activity [ 29].
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