Words similar to neurodegenerative
Example sentences for: neurodegenerative
How can you use “neurodegenerative” in a sentence? Here are some example sentences to help you improve your vocabulary:
Studies have yet to resolve all the mechanisms of action of LC-PUFA, in particular the remarkable phenotypic differences between populations that consume different quantities of fish and fish oil in their diets [ 1 2 3 4 5 ] . Dietary LC-PUFA affect processes including: growth, neurological development, lean and fat mass accretion, reproduction, innate and acquired immunity, infectious pathologies of viruses, bacteria and parasites; and the incidence and severity of virtually all chronic and degenerative diseases including cancer, atherosclerosis, stroke, arthritis, diabetes, osteoporosis, and neurodegenerative, inflammatory, and skin diseases [ 6 7 8 9 10 11 ] . Due to lack of mechanistic knowledge, predictions for optimal intake of nutritionally important LC-PUFA remain vague and dietary recommendations simply relate to prevention of overt deficiency.
It is postulated that tissue injury by these reactive oxygen species accumulates over a long period of time and plays roles in the aging process and the development of heart disease, diabetes, chronic inflammatory diseases, cancer, and several neurodegenerative diseases (Halliwell 1999).
Recent studies on neurodegenerative diseases, including Parkinson's, Alzheimer's and prion diseases, suggest that it is not the long fibrils that produce toxicity and kill neurons, rather, it is the oligomeric aggregation intermediates that produce toxicity [ 54 55 ] . Interestingly, interactions between biomembranes and toxic proteins produce a dual effect of both promoting oligomeric aggregation of the proteins and membrane damage [ 56 57 58 59 ] , suggesting that one possible toxicity of oligomeric aggregates is mediated through damaging membranes.
It is also known that the biological actions of NKA, NKB and SP are mediated by three receptors, named neurokinin (NK)-1, NK-2 and NK-3 [ 2 ] . Thus, the tachykinins have been implicated in several physiological actions such as salivation, the regulation of smooth muscle contraction, depolarization of central neurons, hyperactivity, interaction with dopaminergic A-10 neurons mediating behavioral activation, regulation of blood pressure, and the transmission of the baroreceptor reflex [ 3 4 5 6 7 ] . In addition, a loss of tachykinin-containing neurons has been described in neurodegenerative diseases [ 8 ] , suggesting that the decrease in the amount of tachykinins could be involved in these and other diseases [ 9 10 ] .
However, there are many case reports describing patients with progressive neurodegenerative disorders of unknown etiology, collectively referred to as neuronal intranuclear inclusion disease [ 77 ] . While these may consist mainly of unidentified poly-Gln or poly-Ala disorders, the present study raises the possibility that some forms of this disease may arise through unexpected mechanisms, perhaps involving mutations in Rab24 or other poorly characterized members of the Rab GTPase family that mediate trafficking of misfolded proteins within autophagosomes and lysosomes.
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