Words similar to neurodegenerative
Example sentences for: neurodegenerative
How can you use “neurodegenerative” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mitochondrial vacuolation may contribute to several non-apopototic cell death pathways, but its role in a wide spectrum of neurodegenerative diseases remains to be defined [ 83 84 ] .
Recently, much attention has been given to the neuroprotective properties of estrogens for both chronic neurodegenerative diseases and acute insults such as stroke.
Yet, elevated maternal mid-trimester chorionic gonadotropin is associated with fetal cerebral blood flow redistribution and adverse perinatal outcome [ 63 ] . In addition, estrogens, which are known to cause a diminution of high LH levels in postmenopausal women, have been reported to be effective in the prevention and treatment of Alzheimer's disease [ 72 73 74 ] . Microglia belong among cells of the mononuclear phagocyte system [ 75 ] . Since CG increases secretion of a variety of cytokines by monocytes, and induces their inflammatory reaction and phagocytic activity [ 76 77 78 79 ] , high LH levels in aging individuals may also activate resident macrophages in the central nervous system and contribute to the development of Alzheimer's disease and other inflammation-mediated neurodegenerative diseases.
LHR immunoreactivity in porcine fallopian tubes was confined to the epithelium and smooth muscle cells, and in vitro LH treatment caused relaxation of the oviduct [ 35 ] . Also, LHR stimulation plays a role in the induction and maintenance of myometrial quiescence [ 36 37 38 ] . Since smooth muscles belong among important compartments of the pelvic floor, high LH levels after menopause might be involved in the increased incidence of pelvic floor disorders, a common condition in postmenopausal women [ 39 ] . Since the brain was reported to express functional LHR [ 29 30 ] , there is also a possibility that high LH levels in aging individuals may in some way participate in the development and progression of neurodegenerative process of several degenerative neurological diseases, including Alzheimer's disease.
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
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