Example sentences for: neu

How can you use “neu” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Endocrine therapy with the antioestrogen tamoxifen can mediate the downregulation of c- myc , culminating in cell cycle arrest [ 44 ] . Berns et al . [ 12 ] reported that 38% of patients with amplification of c- myc or with coamplification of c- myc and HER-2 / neu profited from endocrine therapy.

  • In a survey conducted by Ravdin and Chamness [ 24 ] , only one [ 22 ] of 11 studies concerning immunohistochemical overexpression of HER-2 / neu indicated a significant result with respect to OS in multivariate analysis.

  • This ELISA kit was also used to determine Her2/neu protein levels in tissue samples.

  • General details for the double differential PCR technique, reproducibility and clinical significance were described previously [ 17 18 28 40 ] . A cutoff point of more than 2.0 average gene copy number (AGCN) was considered to be positive for HER-2 / neu amplification [ 40 ] . To calculate the cutoff point for c- myc amplification, all NNBC patients were subjected to Classification and Regression Trees (CART) analysis.

  • The first study to mention possible prognostic importance of HER-2 / neu gene amplification was reported in 1987 by Slamon et al . [ 27 ] . That study included 187 patients with NNBC and node-positive breast cancer; by univariate and multivariate analyses, it revealed that HER-2 / neu amplification correlated very closely with shorter DFS and OS in a subgroup of 87 node-positive patients.


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