Example sentences for: neovascularization

How can you use “neovascularization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Rheumatoid arthritis (RA) is characterized by synovial tissue leukocyte infiltration and angiogenesis [ 1 ] . The neovascularization process in RA is dependent on the balance between angiogenic mediators and inhibitors.

  • Interestingly Ang-2 acts as an agonist for Tie2 receptors expressed on fibroblasts [ 6 ] . Since the neovascularization process is dependent on the dominance of angiogenic mediators over inhibitors, the higher Ang-1 mRNA and protein expression compared to Ang-2 in RA synovial tissue is of importance.

  • The ability of cancer cells to proliferate within a tissue depends on their response to adhesive and growth factor cues within the ECM [ 10 ] , and self-sufficiency in growth signals is one of the hallmarks of cancer [ 11 ] . To stimulate their own growth and proliferation in tissue, tumor cells can overproduce and release their own growth factors or obtain them from the matrix as they are released by matrix metalloproteinases [ 12 ] . The endothelial vasculature grows into the tumor and provides nutrients and oxygen [ 13 ] . This model is illustrated by the experimental results presented here, as both A549 (lung) and U118 (brain) cell lines are observed to upregulate one set of genetic programs related to cell growth and proliferation when in culture and another set related to cell adhesion, the extracellular matrix, growth substances, and neovascularization when developing as an in vivo tumor.

  • Hence, all cases had soft drusen present but lacked the advanced lesions of geographic atrophy or choroidal neovascularization.

  • Sp1 is important for the basal expression of various collagens, and blocking Sp1 broadly inhibits expression of ECM genes [ 8 ] . Terms such as 'Pathologic neovascularization' (13,9) and 'Vascular endothelium' (29,26) can refer to processes of angiogenesis, the generation of new blood vessels from preexisting vessels for the delivery of nutrients to tumors.


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