Example sentences for: neovascularization

How can you use “neovascularization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The regulation of MMPs by inflammatory cytokines, and the expression of MMP-9 in macrophages and vascular structures have previously suggested that MMP-9 may be associated with the synovial inflammation and neovascularization [ 35, 36].

  • Macrophages are key angiogenesis effector cells that produce a number of growth factor stimulators and inhibitors, proteolytic enzymes and cytokines that can activate one or more steps in the angiogenesis cascade [ 15 16 17 ] . Recent studies have shown that angiopoietins promote postnatal neovascularization by potentiating angiogenic cytokines such as VEGF [ 9 10 ] .

  • The ability of cancer cells to proliferate within a tissue depends on their response to adhesive and growth factor cues within the ECM [ 10 ] , and self-sufficiency in growth signals is one of the hallmarks of cancer [ 11 ] . To stimulate their own growth and proliferation in tissue, tumor cells can overproduce and release their own growth factors or obtain them from the matrix as they are released by matrix metalloproteinases [ 12 ] . The endothelial vasculature grows into the tumor and provides nutrients and oxygen [ 13 ] . This model is illustrated by the experimental results presented here, as both A549 (lung) and U118 (brain) cell lines are observed to upregulate one set of genetic programs related to cell growth and proliferation when in culture and another set related to cell adhesion, the extracellular matrix, growth substances, and neovascularization when developing as an in vivo tumor.

  • The peripheral cornea was often thinner than normal with neovascularization.

  • VEGF has also been shown to mediate the vessel growth that characterizes tumor expansion as well as the neovascularization that is associated with diabetic retinopathy.


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