Words similar to neovascularization
Example sentences for: neovascularization
How can you use “neovascularization” in a sentence? Here are some example sentences to help you improve your vocabulary:
Several eyes had peripheral corneal thinning while others demonstrated scleralization (opacity) of the peripheral cornea, diffuse corneal haze, or peripheral neovascularization (Figure 2C).
Sp1 is important for the basal expression of various collagens, and blocking Sp1 broadly inhibits expression of ECM genes [ 8 ] . Terms such as 'Pathologic neovascularization' (13,9) and 'Vascular endothelium' (29,26) can refer to processes of angiogenesis, the generation of new blood vessels from preexisting vessels for the delivery of nutrients to tumors.
The regulation of MMPs by inflammatory cytokines, and the expression of MMP-9 in macrophages and vascular structures have previously suggested that MMP-9 may be associated with the synovial inflammation and neovascularization [ 35, 36].
It has been shown that increasing amounts of Ang-2 can block the chemotactic activity of Ang-1 in endothelial cells [ 21 ] . Ang-2 alone did not stimulate corneal neovascularization, but the combination of Ang-2 and VEGF resulted in longer vessels with greater circumferential extent than those seen with VEGF alone [ 9 ] . This suggests that Ang-2 expression in the absence of VEGF leads to vessel regression, whereas expression of Ang-2 in the presence of VEGF potentiates angiogenesis.
The ability of cancer cells to proliferate within a tissue depends on their response to adhesive and growth factor cues within the ECM [ 10 ] , and self-sufficiency in growth signals is one of the hallmarks of cancer [ 11 ] . To stimulate their own growth and proliferation in tissue, tumor cells can overproduce and release their own growth factors or obtain them from the matrix as they are released by matrix metalloproteinases [ 12 ] . The endothelial vasculature grows into the tumor and provides nutrients and oxygen [ 13 ] . This model is illustrated by the experimental results presented here, as both A549 (lung) and U118 (brain) cell lines are observed to upregulate one set of genetic programs related to cell growth and proliferation when in culture and another set related to cell adhesion, the extracellular matrix, growth substances, and neovascularization when developing as an in vivo tumor.
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