Words similar to nearest-neighbor
Example sentences for: nearest-neighbor
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As BLAST hits must be considered imperfect indicators of nearest-neighbor homologs [ 38], the conclusion that the operonic trp -pathway genes are of cyanobacterial lineage origin was confirmed more rigorously by examination of extensive trees (available upon request) constructed for each trp protein of Anabaena and Nostoc . For the Trp-pathway proteins, all the cyanobacterial proteins clustered together, regardless of whether they were Anabaena or Nostoc paralogs or whether they were the singly represented proteins of Synechocystis, Synechococcus , or Prochlorococcus . The same result was obtained for AroA Iβ protein trees.
The binding energy (kcal/mol) is calculated using a nearest-neighbor model using established thermodynamic parameters [ 30, 31, 32, 33, 34, 35].
Missing data were imputed by a simple k -nearest-neighbor algorithm, in which the neighbors are the genes and the distance between neighbors is based on the correlation between their gene-expression levels across arrays.
For a detailed study of methods for filling in missing values in microarray experiments, see [ 41], which suggests that a nearest-neighbor approach provides accurate and robust estimates of missing values.
As described in the text, data was analyzed using a variety of methods, including unsupervised nearest-neighbor hierarchical clustering analyses (GeneSpring [ 28 29 ] [Silicon Genetics], and Cluster [ 25 ] [Stanford University]), t-test (GeneSpring) and four-comparison survival method [ 23 ] . The Cluster and Tree View software were download from http://rana.lbl.govand installed on an NT workstation.