Example sentences for: mvise
How can you use “mvise” in a sentence? Here are some example sentences to help you improve your vocabulary:
Taken together, this study reveals a mitochondrial degeneration mechanism in the CNS, mitochondrial vacuolation by intermembrane space expansion or MVISE.
Our previous study showed that functional decline of mitochondria appears in the SOD1 G93Amice as early as 60 to 100 days of age [ 22 ] . This precedes the peak of mitochondrial vacuolation and the onset of the disease by two to three months [ 15 ] . Mitochondrial dysfunction can lead to energy deficiency and ionic imbalance [ 68 ] , elevated ROS and oxidative damage [ 69 ] , and increased sensitivity of neurons to excitotoxicity [ 19 70 71 72 ] . These effects could precipitate MVISE, which trigger cell death programs by releasing pro-apoptotic proteins resided in the mitochondrial intermembrane space, such as cytochrome c, AIF, SMAC/DIABLO, endo G and Htra/Omi [ 73 ] . The absence of cytochrome c in the porous large vacuoles and the presence of cytochrome c in the small vacuoles (Fig.
Thus, MVISE represents a previously uncharacterized mechanism of mitochondrial degeneration in the CNS.
These features bare resemblances to mitochondrial degeneration in other neurodegenerative conditions, including Alzheimer's disease [ 79 ] , prion disease [ 80 ] , Rett syndrome [ 81 ] , excitotoxic neuronal death [ 70 ] and Mn ++superoxide dismutase (SOD2) deletion [ 82 ] . Although in none of these conditions are sufficiently detailed observations available for a comprehensive comparison, MVISE could play a role in other neurodegenerative disorders.
The presence of peroxisomes in mutant SOD1-induced MVISE is a surprise.
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