Words similar to multistage
Example sentences for: multistage
How can you use “multistage” in a sentence? Here are some example sentences to help you improve your vocabulary:
Human breast tumorigenesis is a multistage process encompassing complex cellular transformation from normalcy to malignancy [ 1 ] . It has been proposed that multiple, different cellular events dictate the biochemical changes that allow normal cells to become highly malignant.
Tolerance induction by parenchymal tissue has also been described [ 20], and may be a multistage process that is still not entirely understood.
Both surveys utilize multistage probability sampling procedures, enabling the generation of nationally representative estimates.
3% of invasive CC, and 11% and 29% of low- and high-grade CIN lesions, respectively [ 12 ] . These authors suggest that RARB methylation is an early event in multistage cervical carcinogenesis.
In some circumstances, CD4 +and CD8 +T cells were rendered inactive in tumor-bearing hosts [ 8 ] . The inactivation of CD4 +T cells has been attributed either to the tumor cells themselves or to bone marrow-derived cells [ 9 10 11 ] , whereas antigen ignorance or loss of memory have been postulated to underlay that of CD8 +T cells [ 12 13 ] . Other studies have suggested that tumor cells can secrete immunosuppressive factors such as TGF-β or express Fas ligand to induce apoptosis of infiltrating lymphocytes [ 14 15 16 ] . Furthermore, the tumor vasculature appears to be quite different from normal blood vessels, in terms of structural organization, interstitial pressure, and flow patterns [ 17 ] , and in reduced lymphocyte and natural killer cell homing and adhesion [ 18 19 20 21 ] . The existence of significant barriers to effective immunological destruction is further illustrated by a mouse model of concurrent multistage tumorigenesis and anti-oncogene autoimmunity, wherein progenitor dysplastic lesions are infiltrated and disrupted, while solid tumors are not [ 22 ] . The hypothesis is that the microenvironment of certain types of solid tumor can serve to locally suppress T cell infiltration.
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