Words similar to multistage
Example sentences for: multistage
How can you use “multistage” in a sentence? Here are some example sentences to help you improve your vocabulary:
Gastric carcinogenesis is considered as a multistage progressive process.
Additional support for the utility of medical record surveillance information comes from comparison of our data to that collected by the National Ambulatory Medical Care Survey (NAMCS) [ 9 ] , which uses multistage sampling of ambulatory care physicians, requiring participants to report a random sample of patients seen in a randomly assigned week.
Human breast tumorigenesis is a multistage process encompassing complex cellular transformation from normalcy to malignancy [ 1 ] . It has been proposed that multiple, different cellular events dictate the biochemical changes that allow normal cells to become highly malignant.
In some circumstances, CD4 +and CD8 +T cells were rendered inactive in tumor-bearing hosts [ 8 ] . The inactivation of CD4 +T cells has been attributed either to the tumor cells themselves or to bone marrow-derived cells [ 9 10 11 ] , whereas antigen ignorance or loss of memory have been postulated to underlay that of CD8 +T cells [ 12 13 ] . Other studies have suggested that tumor cells can secrete immunosuppressive factors such as TGF-β or express Fas ligand to induce apoptosis of infiltrating lymphocytes [ 14 15 16 ] . Furthermore, the tumor vasculature appears to be quite different from normal blood vessels, in terms of structural organization, interstitial pressure, and flow patterns [ 17 ] , and in reduced lymphocyte and natural killer cell homing and adhesion [ 18 19 20 21 ] . The existence of significant barriers to effective immunological destruction is further illustrated by a mouse model of concurrent multistage tumorigenesis and anti-oncogene autoimmunity, wherein progenitor dysplastic lesions are infiltrated and disrupted, while solid tumors are not [ 22 ] . The hypothesis is that the microenvironment of certain types of solid tumor can serve to locally suppress T cell infiltration.
The mice show systemic tolerance to Tag, mounting neither humoral nor cellular immune responses to Tag upon immunization of purified protein [ 25 26 ] . Rip1-Tag2 mice display a reproducible pattern of multistage tumor development, from normal islets to hyperplastic/dysplastic islets, to angiogenic islets, to varying grades of solid tumor, with a well-defined angiogenic progression [ 27 ] . All Rip1-Tag2 mice succumb to hypoglycemia and tumor burden by 13-16 weeks.
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