Words similar to mtr
Example sentences for: mtr
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By this approach, TAB1 was revealed to be MTR10, a gene previously implicated in nuclear transport [ 35 36 37 ] . We were unable to isolate plasmids that complemented tab3 in all libraries tested.
The only phenotype known to be shared by srp1, mtr10, and kap104 mutants is accumulation of the 60S ribosomal protein Rpl11b in the nucleus [ 39 ] . SRP1, MTR10, and KAP104 may also collaborate to maintain the proper nucleocytoplasmic partitioning of α factor (or factors) that regulates mitotic exit.
Both MTR10 (TAB1 ) and SRP1 belong to the nuclear transport receptor/adaptor family (reviewed by [ 38 ] ). Mutant srp1-31 and mtr10 tab 1-1cells accumulate the ribosomal protein Rpb11b in the nucleus [ 39 ] . Thus, to evaluate a potential link between nuclear transport and the tab phenotype, we evaluated the localization of Rpl11b-GFP [ 39 ] in all tab mutants.
Mtr10 assembles with and functions as a nuclear import receptor for the mRNA-binding protein Npl3 [ 36 37 ] . Interestingly, srp1-31 also inhibits nuclear import of multiple proteins including Npl3 [ 51 52 ] . Remarkably, reduction-of-function alleles of the karyopherin KAP104 were also recovered in a screen for mutations that suppressed cdc15-2 ts (A.
Resistance to polymyxin B is also imparted by the absence or masking of critical binding sites required for polycation-mediated permeabilization of the outer membrane [ 54 ] . Thus, attachment of polymyxin B to Yersinia enterocolitica is reduced by steric hindrance generated by the size and/or branched shape of the outer core region of its LPS macromolecule [ 55 ] . Additionally, resistance to cationic peptides can be due to cytoplasmic clearance of the antimicrobial peptide by an efflux pump; e.g., Yersinia resistance to polymyxin B caused by the RosA/RosB efflux pump/potassium antiporter [ 56 ] and Neisseria gonorrhoeae resistance to protegrin PG-1 via an energy-dependent efflux system termed mtr [ 57 ] .
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