Example sentences for: mtor
How can you use “mtor” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus expression of the mutant mimics the effects of rapamycin on 4EBP but does not affect the other targets of mTOR.
Cumulatively, however, these observations do suggest a mechanism whereby HIV-1 expression in renal epithelium may induce cyclin D 1 : activation of Src-family kinases by Nef would be expected to up-regulate cyclin D 1 gene expression and promote the synthesis and stabilization of cyclin D 1 protein via Src-Ras-MAPK and Src-PI3K-mTOR signal transduction pathways, respectively [ 32 33 34 ] . Interestingly, our unpublished in vitro observations and published data showing marked expression of basic fibroblast growth factor in the interstitium of HIVAN kidneys [ 35 ] suggest that soluble mitogens may be important cofactors with HIV-1 expression to induce cyclin D 1 . Thus, interrupting HIV-1 gene expression should down-regulate cyclin D 1 and correct the phenotypic abnormalities in infected podocytes.
mTOR is a serine/threonine kinase that is activated by insulin, nutrients, and growth factors and is a central regulator of ribosome biogenesis, protein synthesis, and cell growth.
However, it is likely that carbohydrate and protein may differentially alter nutrient-sensing pathways such as Sir2 and mammalian target of rapomyocin (mTOR), which are gaining acceptance as mediators of the life-span extension effects of CR [16].
Rapamycin inhibits activation of p70 S6 kinase, a downstream effector in the PI 3-kinase signaling pathway [ 13 ] . Rapamycin forms a complex with FK506-binding protein 12 and this complex blocks the kinase activity of mTOR (mammalian target of rapamycin), a kinase upstream of p70 S6 kinase [ 20 ] . The IC 50 for p70 S6 kinase inhibition by rapamycin is ~0.
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