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Example sentences for: msto-

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Human tumor cell lines - LS1034 colorectal carcinoma (ATCC Number: CRL-2158), SW480 colorectal adenocarcinoma (ATCC Number: CCL-228), MSTO-211H biphasic mesothelioma (ATCC Number: CRL-2081) and HepG2 hepatocellular carcinoma (ATCC Number: HB-8065) - were purchased from American Type Culture Collection.
MSTO-211H, mesothelioma, cell line also showed a weak induction of MHCII in response to IFNg and HepG2, hepatocellular carcinoma, was completely non-inducible (data not shown).
A closer look at Figure 5reveals that the 4 cell lines can be ranked according to their Rb contents in the following order: SW480 > LS1034 > MSTO-211H > HepG2.
PMA did not improve IFNg inducibility of MHCII in MSTO-211H and HepG2 cell lines (data not shown).
A substantial percentage of human tumors lose the expression of the retinoblastoma tumor suppressor protein (Rb), important as a necessary condition for IFNg-mediated induction of MHCII [ 21 ] . Therefore, we wished to determine whether the poor IFNg inducibility of MHCII in LS1034, MSTO-211H and HepG2 cell lines could be explained by the loss of Rb.