Words similar to mpf

Example sentences for: mpf

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In the M II oocyte, the membrane of the donor nucleus is broken down and the chromosomes are prematurely condensed due to the high activity of MPF.
In the preactivated oocyte, the nuclear membrane of the donor cells remains intact due to the low activity of MPF and DNA synthesis occurs according to the original cell cycle stage at the time of nuclear transfer [ 12] and nuclear reprogramming occurs during the expansion of the donor nucleus [ 18, 19].
The secreted form has been referred to as megakaryocyte potentiating factor (MPF) for its ability to stimulate the megakaryocyte colony forming activity of murine IL-3 in mouse bone marrow cell culture [ 23 24 ] . Mesothelin expression is induced in a variety of cancers including ovarian, pancreatic, lung, and cervical cancer [ 25 26 ] . The soluble portion of mesothelin has drawn attention as a potential serum tumor marker since it is highly over-expressed in patients with ovarian carcinomas and pancreatic adenocarcinomas [ 27 28 ] .
Because many studies suggest that exposure to high activity of MPF is effective for reprogramming a donor nucleus from a differentiated cell [ 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14], M I oocytes may reprogram somatic cell nuclei as well.
When donor nuclei are transferred into non-treated M II recipient oocytes that have high MPF activity, various changes referred to as nuclear remodeling occur in the introduced nuclei.