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Example sentences for: mpf

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The secreted form has been referred to as megakaryocyte potentiating factor (MPF) for its ability to stimulate the megakaryocyte colony forming activity of murine IL-3 in mouse bone marrow cell culture [ 23 24 ] . Mesothelin expression is induced in a variety of cancers including ovarian, pancreatic, lung, and cervical cancer [ 25 26 ] . The soluble portion of mesothelin has drawn attention as a potential serum tumor marker since it is highly over-expressed in patients with ovarian carcinomas and pancreatic adenocarcinomas [ 27 28 ] .
In addition to MPF, mitogen-activated protein (MAP) kinase is also known as an important protein kinase that regulates the meiotic cell cycle [ 35].
MPF activity during oocyte maturation is maximal at both M I and M II [ 12].
Because many studies suggest that exposure to high activity of MPF is effective for reprogramming a donor nucleus from a differentiated cell [ 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14], M I oocytes may reprogram somatic cell nuclei as well.
In the preactivated oocyte, the nuclear membrane of the donor cells remains intact due to the low activity of MPF and DNA synthesis occurs according to the original cell cycle stage at the time of nuclear transfer [ 12] and nuclear reprogramming occurs during the expansion of the donor nucleus [ 18, 19].