Words similar to motifs
Example sentences for: motifs
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The protein encoded by ORF2S (designated PEVE E1) is homologous to the helicase domain of superfamily 3 (SF3) viral helicases, such as E1 proteins of papillomaviruses (Figure 3) [ 18 19 20 ] . Similar to SF3 helicases, the PEVE E1 domain contains a P-loop (motif A) and two conserved motifs (B and C) that determine helicase function [ 18 19 ] . However, unlike SF3 helicases, PEVE E1 contains only the helicase domain with no additional protein domains.
Interestingly, not all yeast prions have similar oligopeptide repeat motifs, indicating that distinct structures could confer prion properties to polypeptides that can aggregate.
It might also be useful to make training sets consisting of subsets of promoters that share combinations of motifs and use a collection of McPromoter variants each trained on a different class of core promoter.
The hyperthermophilic topoisomerase I from Thermotoga maritima has been shown to coordinate one Zn(II) with a unique tetracysteine motif Cys-X-Cys-X 16 -Cys-X-Cys but Zn(II) binding is not required for relaxation activity [ 33 ] . The sequence of this unique tetracysteine motifs is somewhat different from those present in other type IA topoisomerases in that the other tetracysteine motifs always had at least two amino acids separating the pairs of cysteines (Cys-X 2-11 -Cys), instead of just one amino acid (Cys-X-Cys) in T. maritima topoisomerase I [ 33 ] . Therefore the structure and function of the single Zn(II) binding motif in T. maritima may differ from the multiple Zn(II) binding motifs in E. coli topoisomerase I. Direct interaction between DNA and the T. maritima Zn(II) binding motif has not been demonstrated.
These data indicate that the v-crk SH2 domain interacts with the C-terminal YDXP motifs, and as suggested by Birge et al, v-crk may be able to protect them from dephosphorylation and/or induces their phosphorylation [ 12 ] . They also suggest that the YQXP motifs may be involved in binding to other intracellular signaling molecules.
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