Words similar to monotonic
Example sentences for: monotonic
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Pairwise covariation of 3:1 dinucleotide frequencies was assessed by the Spearman rank correlation coefficient [ 45], a nonparametric rank statistic for testing monotonic relationships.
Initial simulation estimates based on monotonic population expansion suggested that useful LD was unlikely to extend beyond 3 kb, implying a number of 500,000 SNPs necessary for a whole-genome scan [ 32 ] . Another study looking at real data found that LD extended over much larger distances and arrived at an estimate as small as 30,000 SNPs, or 1 SNP per 100 kb [ 33 ] . Recent evidence suggests that the genome consists of blocks of high LD (haplotype blocks) separated by recombination hot spots [ 34 ] . Within each block, a limited number of common haplotypes (three to five) typically capture about 90% of all chromosomes, which means that a reduced number of SNPs would be needed to characterize these haplotypes [ 35 ] . Thus, the recently initiated construction of a haplotype map of the human genome may facilitate selection of SNP markers for genomewide association studies like ours.
A U-shaped curvilinear relationship between sleep duration and BMI was observed for women, but for men, there was a monotonic trend towards higher BMI with shorter sleep duration.
Spearman's rank order correlation determined significant monotonic relationships that illuminate important connections between structural features in tissue elements and genes that have been reported as significantly up- or downregulated by CCl 4 treatment in previous studies [ 7 ] . Principal component analysis (PCA), as described in Materials and methods, was carried out to reduce the complexity of the data [ 15 ] and then to relate individual animals to specific phenotypic groups.
27 All the statistics presented are monotonic across28 quartiles except for route type.
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