Words similar to moiety
Example sentences for: moiety
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This type of clonal evolution to the recognition of different epitopes on the same immunogenic moiety is common in experimental situations in which repetitive immunizations with a defined antigen are delivered [ 29, 30, 31].
Whether sulfur transferase functionality is retained in the rhodanese-like domains of MoeBR and MoeZ and whether these proteins can function to activate a substrate as well as transfer a sulfur-containing moiety is unknown.
The Hh protein used in the studies described here was bacterially overexpressed amino-terminal human Shh modified at its amino-terminal cysteine by an octyl maleimide moiety [ 21 ] . This lipophilic Shh form showed comparable potency to native Shh in the cell-based reporter assay (data not shown).
Surprisingly, the ester moiety of acetylcholine does not seem to interact with the cys-loop of the receptor, as previously suggested by photoaffinity labeling [ 12 ] , but is engaged in similar type of interaction as that observed with the acidic group of HEPES in the AChBP crystal structure [ 6 ] . It is possible that the reactive di-azo group of the photosensitive agonist used in photoaffinity labeling would extend towards the cys-loop, while the conformation of the bound agonist remains in agreement with our model.
The anti-inflammatory activity of SSZ is due to the 5-aminosalicylic acid component while the majority of the adverse side effects have been attributed to the sulfapyridine moiety [ 14 15 16 ] . Fever, abdominal pain, and rash may develop in 3% to 20% of treated patients, but these side effects are usually mild and improve with dose reduction [ 7 11 12 ] . Severe side effects necessitating SSZ discontinuation occur in less than 5% of treated patients [ 11 ] .