Words similar to moiety
Example sentences for: moiety
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This might be due to the polysaccharide backbone of cellulose [ 60 ] with a propensity to form strong intermolecular hydrogen bonds and to be involved in hydrophobic interactions more than soluble dextrans [ 61 ] and galactose + 3,6-anhydrogalactose copolymers (= the saccharide moiety of carrageenan) [ 62 63 ] . Among the two polymers containing aryl sulfonates, poly(napthalene sulfonate) was more effective than poly(styrene-4-sulfonate) with respect to induction of gp41 six-helix bundles in HIV-1 BaL.
The Hh protein used in the studies described here was bacterially overexpressed amino-terminal human Shh modified at its amino-terminal cysteine by an octyl maleimide moiety [ 21 ] . This lipophilic Shh form showed comparable potency to native Shh in the cell-based reporter assay (data not shown).
This design resulted in a uniform array of biotinylated tiles, with each biotin moiety separated by about 19 nm.
These hybrid molecules activate transcription [ 9 31 ] . It may be possible to produce small-molecule activators (or repressors) that bind DNA specifically, but also activate transcription of adjacent genes through a non-peptidic, more drug-like moiety.
The hedgehog ( hh ) gene was identified two decades ago in Drosophila as a critical regulator of cell-fate determination during embryogenesis [ 1 ] . Subsequent work in several model systems has defined and characterized the Hh gene family that encodes highly conserved secreted signaling proteins (for review see [ 2 ] ). Hedgehog (Hh) proteins are synthesized as approximately 45 kDa precursors that autoprocess in an unprecedented fashion, resulting in the covalent attachment of a cholesterol moiety to the amino-terminal half of the precursor [ 2 ] . This processed amino-terminal domain, Hh-Np, is responsible for the activation of a unique and complex signaling cascade that is essential for controlling cell fate throughout development and into adulthood [ 2 ] . In mammals there are three Hh-family proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh).
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