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Sacco and Moghissi detected zona pellucida antibodies in both men and women by indirect immunofluorescence, but they used porcine rather than primate zonae pellicidae [ 27 ] . Normal animal and human serum are known to contain a wide range of low-titer autoantibodies that have been termed "natural autoantibodies" [ 28 ] . Even B cells from newborn mice and human cord blood produce these natural autoantibodies [ 29 30 31 ] . The low titer ovarian antibodies that we demonstrate here in the serum of normal women are likely natural autoantibodies, and not antibodies with any pathophysiologic significance.