Words similar to modifiers
Example sentences for: modifiers
How can you use “modifiers” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, careful phenotypic comparisons between the AKXD28 and D2 strains suggests that the AKXD28 genome contains genetic modifiers that suppress pigment dispersion and increase susceptibility to pressure-induced retinal damage.
Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.
This does not rule out the evolutionary theory of recombination modifiers, or that the location and intensity of recombination hotspots may evolve rapidly, but it does suggest that we may not need to invoke the evolutionary modifier theory to explain the existence of recombination hotspots.
Future studies will reveal whether some of the other described functions of CSN also involve post-translational modification of regulatory proteins by ubiquitin-like modifiers.
Possible explanations for such cases include duplications which we may have missed, mutations in unknown enhancers or translation modifiers hidden in exons or introns, mutations that create novel splice sites and changes in the coding region which might be pathogenic but which, due to our lack of knowledge, are thought to be polymorphic.
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