Words similar to mmtv-

Example sentences for: mmtv-

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MMTV- Wnt-1 TG mice [ 27] and those that carry a mutant allele of Pten [ 25] have been described.
After one mutated allele of Pten was bred into this transgenic line, tumors appeared significantly earlier than in sibling females harboring only a MMTV- Wnt-1 transgene (P < 0.001, Fig.
The median age at which tumors are detected is 5-6 months in MMTV- Wnt-1 TG females [ 27, 28, 30, 31].
In order to produce such a model for studying the effects of Pten mutations in breast cancer, we have crossed Wnt-1 TG mice to mice heterozygous for Pten . Mice transgenic for MMTV- Wnt-1 and heterozygous for Pten developed mammary adenocarcinomas much earlier than mice carrying either lesion alone.
In an effort to develop a model for studying the effects of Pten inactivation in mammary oncogenesis, we have introduced an additional genetic alteration, an MMTV- Wnt-1 transgene, by breeding Pten heterozygotes [ 25] with MMTV- Wnt-1 transgenic (TG) mice [ 27].