Words similar to mmp-
Example sentences for: mmp-
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Triterpenoids are a novel family of steroid-like compounds with weak anti-inflammatory properties [ 18 ] . Synthetic triterpenoids have been produced with the aim of achieving increased potency [ 19 20 ] . 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) is a synthetic triterpenoid that has been shown to inhibit expression of the inflammatory genes inducible nitric oxide synthase and cyclo-oxygenase-2 [ 20 21 22 ] . In a recent report, MMP-1 and MMP-13 expression were induced with IL-1, a known pro-inflammatory mediator in vivo in joint tissues [ 23 ] . It was shown that CDDO could inhibit the IL-1-induced expression of these pro-inflammatory MMPs.
[ 3 ] ) that include tissue plasminogen activator [ 5 ] , reactive oxygen species such as O 2 - [ 6 7 ] , cytokines like TNF-α [ 7 8 ] and proteases, in particular MMP-9 [ 7 9 ] , in a time- and concentration-dependent manner.
However, immunoblot analysis using a polyclonal antibody to human MMP-1 (this reagent is not available for the chicken homologue of this matrix metalloproteinase) showed that cCAF treatment caused a decrease in the amount of the collagenase MMP-1 detected, but neither TIMP-1 nor TIMP-2 (two natural inhibitors of these MMPs) levels were changed, as evaluated by immunoblot analysis with a monoclonal antibody to the corresponding human proteins (Fig.
Tissue expression of MMP-14, the activator for pro-MMP-2, was significantly higher in RA than in non-RA patients (8.
Synovial tissue expressions of MMP-2, MMP-14, and TIMP-2 were virtually undetectable in all normal volunteers; MMP-9 expression was observed in an isolated area of one normal synovial tissue sample.
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