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Example sentences for: mmcop

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Unlike GFP-ΔN70, GFP-ΔRING (amino acid 226-773) was only found in the cytoplasm in all the cells examined (Fig 5Aand 5B), suggesting that the NLS of MmCOP1 is probably located within amino acid 71 to 226 of MmCOP1.
This speculation would be consistent with the fact that the subcellular localization of AtCOP1 is regulated by light only in certain types of plant cells [ 14 ] . Furthermore, the protein fragments responsible for regulating subcellular localization of AtCOP1 are quite conserved in MmCOP1, which may explain why the mammalian COP1, when expressed in onion epidermal cells, can be regulated by light in a similar manner as AtCOP1 [ 20 ] . However, the same nuclear translocation signal of AtCOP1 has been used in all plant cell types examined [ 17 19 ] , which argue against the later hypothesis.
We were also able to identify the full-length genomic sequence of mosquito COP1 (Anopheles gambiae COP1 , AgCOP1 ) and partial genomic sequences of MmCOP1 and fugu COP1 (Fugu rubripes COP1 , FrCOP1 ). The genomic structures of the vertebrate COP1 genes appear to be generally conserved among themselves, but different from mosquito and plant COP1 genes (data not shown).
However, GFP-ΔN70 does not display NE localization pattern, indicating that the first 70 amino acid of glycine-serine rich region may be responsible for targeting MmCOP1 to the NE (Fig 5Aand 5B).
Comparison of the subcellular localization signals uncovers clear distinctions between AtCOP1 and MmCOP1.