Words similar to mmac

Example sentences for: mmac

How can you use “mmac” in a sentence? Here are some example sentences to help you improve your vocabulary:

In particular, mutations of genes regulating cell adhesion molecules have been reported to be metastasis-fostering alterations [ 5 6 7 8 ] . In human breast cancers, several other genes have been found to be associated with metastasis, namely nm23 [ 9 10 ] , KAI1 [ 11 12 ] , mta1 [ 13 ] , KiSS1 [ 14 ] , PTEN/MMAC1 [ 15 16 ] and BRMS1 [ 17 ] .
The molecular mechanisms leading to breast malignancies are unclear, but many genetic abnormalities and epigenetic factors have been implicated, including changes affecting known tumor suppressor genes ( p53 , BRCA1, BRCA2 , PTEN/MMAC1/TEP1) and proto-oncogenes (neu/ErbB2/HER2 , ErbB1/EGFR , PRAD-1/cyclin D1 , Mdm2 , and c-myc) [reviewed in ref.
The tumor suppressor gene PTEN (also called MMAC1) has been found deleted or mutated in a great variety of human tumors and tumor cell lines [ 1 2 3 ] , and its tumor suppressing function has been confirmed in several in vitro studies [ 4 5 6 7 8 9 10 ] . Mice which are homozygously deficient in wild-type PTEN die during embryonic development and harbor regions of increased cellular proliferation, whereas heterozygous mice are viable but spontaneously develop tumors of various origins [ 11 12 ] .