Words similar to mkp

Example sentences for: mkp

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PP2 is a serine/threonine phosphatase which dephosphorylates JNK during inflammatory cell signaling [ 19 ] , while MKP5 is a member of the dual specificity phosphatase family which selectively dephosphorylates stress activated MAP kinases including JNK [ 20 ] . The overexpression of these two phosphatases might contribute in part to the resistance of HL60/TLK286 by impairing the activity of JNK.
For example, the stress kinase JNK1 was activated during TLK286 induced apoptosis [ 17 ] and JNK is known to be activated during apoptosis induced by a variety of stress stimuli [ 18 ] . However, in HL60/TLK286 resistant cells, we observed an overexpression of two phosphatases PP2 (AA599092) and MKP5 (AA056608) involved in JNK dephosphorylation and inactivation (Table 2).
According to their kinetics of expression, the large majority of genes were identifiable approximately 3 hours after IL-2 exposure, with the exception of a subgroup including transcription and regulatory factors (c-Fos, MKP1) which underwent early and short-lived upregulation.