Words similar to missegregation

Example sentences for: missegregation

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Although they exhibit a striking difference in their apparent MI nondisjunction frequencies, the rec12-D15 (null) and rec12-Y98F (active site) mutants manifest at most a two-fold difference in the absolute frequency of meiotic diploids exhibiting MII missegregation patterns (Figures 4, 5, Table 2).
However, about half of the diploids from rec12-117 and rec12-D15 meioses, and 14% of diploids from rec12-Y98F meioses, exhibited mixed patterns of MI or MII missegregation for different chromosomes within individual cells (Table 2).
Catalytically-inactive Rec12-Y98F protein apparently cannot enhance the fidelity appropriate MII segregation, relative to MII missegregation levels in cells lacking Rec12 entirely.
Those data were compared to the inheritance patterns predicted for each type of chromosome missegregation (Figure 5).
At present, two hypothetical mechanisms by which a Rec12-dependent signal affects MII are proposed: First, Rec12-dependent (recombination-dependent) signals might trigger a block after MI, thereby allowing cells to skip a frequently irregular MII division [ 39 ] . However, the majority of the rec12 mutant meioses show evidence of two meiotic divisions (Figure 3) and many of the meiotic diploids exhibit mixed MI and MII missegregation patterns for centromere linked markers on the three different chromosomes (Table 2).