Words similar to missegregation
Example sentences for: missegregation
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However, about half of the diploids from rec12-117 and rec12-D15 meioses, and 14% of diploids from rec12-Y98F meioses, exhibited mixed patterns of MI or MII missegregation for different chromosomes within individual cells (Table 2).
Although they exhibit a striking difference in their apparent MI nondisjunction frequencies, the rec12-D15 (null) and rec12-Y98F (active site) mutants manifest at most a two-fold difference in the absolute frequency of meiotic diploids exhibiting MII missegregation patterns (Figures 4, 5, Table 2).
Those data were compared to the inheritance patterns predicted for each type of chromosome missegregation (Figure 5).
Irregular partitioning of chromosomes during the second meiotic division has also been reported in fission yeast rec7 mutants [ 10 ] , so MII missegregation may be a relatively common fate for chromosomes in hyporecombination mutants.
Catalytically-inactive Rec12-Y98F protein apparently cannot enhance the fidelity appropriate MII segregation, relative to MII missegregation levels in cells lacking Rec12 entirely.
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