Words similar to misregulation
Example sentences for: misregulation
How can you use “misregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Interestingly, mesothelin expression is induced in lung, ovarian, and pancreatic carcinomas where constitutive activation of Wnt signaling is caused by stabilizing mutations in beta-catenin [ 27 28 41 42 43 44 ] . The induction of mesothelin in these carcinomas may be due to misregulation of Wnt signaling as are other targets of the Wnt pathway, c-myc and cyclin D1.
Disruption of ifkAresults in misregulation of countin
We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.
The combination of microarray data and cluster analysis to make a genetic portrait of a disease has been used to characterize breast tumors [ 9], to categorize the subtype of diffuse large B-cell lymphoma [ 10], and to identify genes whose expression is associated with mitotic misregulation and human aging [ 11].
This methodology [ 8] has been used by others to define the gene-expression profile of breast tumors [ 9], to subtype diffuse large B-cell lymphomas [ 10] and to identify genes whose expression is associated with mitotic misregulation and human aging [ 11].
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