Words similar to misregulation
Example sentences for: misregulation
How can you use “misregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although complementary sites for both miRNAs are found in the 3' UTRs of several putative nematode targets, these miRNAs are not physically linked in the C. elegans genome and their mutant phenotypes are principally due to misregulation of different transcripts [ 4 5 6 8 ] . The function of these miRNAs has not yet been explicitly demonstrated in other species, but Drosophila let-7 is regulated at the larval-pupal transition by ecdysone [ 49 ] , and all three members of this cluster are present in other insects and in vertebrates, thus implying broadly conserved functions.
We have shown that disruption of a single splice donor site within a multi-exon locus can lead to a dramatic misregulation of RNA splicing.
This methodology [ 8] has been used by others to define the gene-expression profile of breast tumors [ 9], to subtype diffuse large B-cell lymphomas [ 10] and to identify genes whose expression is associated with mitotic misregulation and human aging [ 11].
Interestingly, mesothelin expression is induced in lung, ovarian, and pancreatic carcinomas where constitutive activation of Wnt signaling is caused by stabilizing mutations in beta-catenin [ 27 28 41 42 43 44 ] . The induction of mesothelin in these carcinomas may be due to misregulation of Wnt signaling as are other targets of the Wnt pathway, c-myc and cyclin D1.
The combination of microarray data and cluster analysis to make a genetic portrait of a disease has been used to characterize breast tumors [ 9], to categorize the subtype of diffuse large B-cell lymphoma [ 10], and to identify genes whose expression is associated with mitotic misregulation and human aging [ 11].
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