Words similar to misregulation
Example sentences for: misregulation
How can you use “misregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although complementary sites for both miRNAs are found in the 3' UTRs of several putative nematode targets, these miRNAs are not physically linked in the C. elegans genome and their mutant phenotypes are principally due to misregulation of different transcripts [ 4 5 6 8 ] . The function of these miRNAs has not yet been explicitly demonstrated in other species, but Drosophila let-7 is regulated at the larval-pupal transition by ecdysone [ 49 ] , and all three members of this cluster are present in other insects and in vertebrates, thus implying broadly conserved functions.
We have shown that disruption of a single splice donor site within a multi-exon locus can lead to a dramatic misregulation of RNA splicing.
Disruption of ifkAresults in misregulation of countin
We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.
The combination of microarray data and cluster analysis to make a genetic portrait of a disease has been used to characterize breast tumors [ 9], to categorize the subtype of diffuse large B-cell lymphoma [ 10], and to identify genes whose expression is associated with mitotic misregulation and human aging [ 11].
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