Words similar to misfolded

Example sentences for: misfolded

How can you use “misfolded” in a sentence? Here are some example sentences to help you improve your vocabulary:

Interestingly, Rab24 has been implicated as a possible mediator of autophagy in a recent study where wild-type GFP-Rab24 was observed to accumulate on large autophagic vacuoles in cells subjected to amino acid starvation [ 43 ] . Thus, if Rab24(D123I) functions as a true dominant suppressor of endogenous Rab24, the inclusions observed in the present study may consist of misfolded endogenous proteins that cannot be degraded because basal activity of the autophagosome-lysosome pathway is blocked.
They can act as anti-oxidants (to prevent damage from oxygen radicals), as chaperones (to prevent misfolded proteins from forming aggregates), as antimicrobials (to protect against bacteria and fungi), and as metabolic agents.
Between these two effects, it is likely that cells with aggregated α-synuclein will become less able to handle damaged or misfolded proteins.
ER function is critical if protein synthesis and folding is to successfully occur in eukaryotic cells [ 11 12 ] . ER stress, induced by cellular events as diverse as disrupted calcium homeostasis, elevated levels of reactive oxygen species and viral infection, leads to accumulation of dysfunctional ER chaperones and misfolded proteins [ 11 ] . Cells respond by one or both of two conserved stress response pathways.
Therefore, the first possibility is that the presence of Hsp70 and ubiquitin reflects a failed attempt by the cell to eliminate misfolded protein aggregates via the proteasome pathway.