Words similar to miracl
Example sentences for: miracl
How can you use “miracl” in a sentence? Here are some example sentences to help you improve your vocabulary:
The types of events prevented in MIRACL are also worth noting.
The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) trial set out to answer this question.
Although lipid-lowering therapy was associated with a significantly lower mortality when initiated early after an acute coronary syndrome in two large observational studies [ 6 7 ] , MIRACL was the first randomized trial to suggest that statins confer clinical benefits in this setting.
And, while clinical trial safety endpoints may be considered less glamorous, MIRACL's most important contribution may have been that high-dose statin therapy was not associated with serious harm, despite its use in the unstable setting.
Even if these findings are not confirmed after further study, one could still make a compelling argument that lipid-lowering therapy (barring contraindications) should be initiated early and universally in patients who present with an acute coronary syndrome: First, the long-term safety and effectiveness of statins for the secondary prevention of stable coronary disease is well-established [ 1 2 3 ] ; Second, as evidenced by MIRACL, these agents are safe when initiated at the time of hospitalization for an acute coronary syndrome; Third, the in-hospital initiation of lipid-lowering therapy appears to promote greater long-term utilization of these agents [ 18 19 20 21 ] . Finally, although lipid levels may be unreliable in the setting of an acute coronary syndrome (excepting total :HDL and LDL:HDL cholesterol ratios [ 22 ] ) the overwhelming majority of patients with coronary disease will ultimately require both pharmacologic and non-pharmacologic lipid-lowering interventions to attain recommended cholesterol targets [ 23 24 25 ] ; newer guidelines are even more stringent [ 26 ] . Furthermore, data from the recently presented Heart Protection Study suggest that clinical benefits may accrue independent of baseline cholesterol level [ 4 ] . Thus, to withhold lipid-lowering therapy from patients who present with an acute coronary syndrome would be to accept the status quo, and to date our efforts at cholesterol lowering in the secondary prevention setting have been dismal [ 27 28 ] .
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